Evidence map›Paper›PMID 31675305›Full record

ArticleRambam Maimonides medical journal2019

Expression Pattern of the Cancer Stem Cell Marker "Nestin" in Leukoplakia and Oral Squamous Cell Carcinoma.

Kushbu Narender Singh, Madhavan Nirmal Ramadas, Veeravarmal Veeran, Murali Radhakrishnan Naidu, Thamarai Selvi Dhanaraj, Kalyani Chandrasekaran

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rambam Maimonides medical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kushbu Narender SinghDivision of Oral and Maxillofacial Pathology, Rajah Muthiah Dental College & Hospital, Annamalai University, Tamilnadu, India.
Madhavan Nirmal RamadasDivision of Oral and Maxillofacial Pathology, Rajah Muthiah Dental College & Hospital, Annamalai University, Tamilnadu, India.
Veeravarmal VeeranDivision of Oral and Maxillofacial Pathology, Rajah Muthiah Dental College & Hospital, Annamalai University, Tamilnadu, India.
Murali Radhakrishnan NaiduDivision of Oral and Maxillofacial Pathology, Rajah Muthiah Dental College & Hospital, Annamalai University, Tamilnadu, India.
Thamarai Selvi DhanarajDivision of Oral and Maxillofacial Pathology, Rajah Muthiah Dental College & Hospital, Annamalai University, Tamilnadu, India.
Kalyani ChandrasekaranDivision of Oral and Maxillofacial Pathology, Rajah Muthiah Dental College & Hospital, Annamalai University, Tamilnadu, India.
Annamalai University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of the present study was to determine and compare the expression pattern and localization of nestin, in an attempt to explore its role in oral carcinogenesis.

methodsWestern blot and immunohistochemistry analysis were performed to study the expression pattern of nestin in normal mucosa, leukoplakia, and oral squamous cell carcinoma samples. Nestin expression was evaluated in the keratinocytes and blood vessels of all the samples and compared with various clinico-pathological parameters.

resultsNestin expression was increased in samples of leukoplakia and oral squamous cell carcinoma when compared with normal mucosa. Among leukoplakia samples, the expression was increased in cases without dysplasia compared to cases with dysplastic features. In cases of oral squamous cell carcinoma, the expression of nestin was found to be decreased with the loss of differentiation. Neoangiogenesis status determined by nestin expression showed an increasing expression from normal mucosa through leukoplakia, to oral squamous cell carcinoma.

conclusionThis study has two major findings: (1) identification of nestin as an effective indicator of neoangiogenesis, and (2) nestin may be used as a marker in predicting the early changes in oral carcinogenesis.

Identifiers

PMID31675305
PMCPMC6824828
OpenAlexW2982485846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.