ArticleHippocampus2020
Characterization of hippocampal subfields using ex vivo MRI and histology data: Lessons for in vivo segmentation.
Article in Hippocampus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Age-related differences in hippocampal subfield volumes across the human lifespan: A meta-analysis.Hippocampus · 2023Pooled it
- Review
- Characterizing the MRI signature of hippocampal sclerosis of aging.Alzheimer's research & therapy · 2026Article
- An open-source stereotaxic container with an integrated cutting guide for human brain fixation during magnetic resonance imaging and sectioning for histology.bioRxiv : the preprint server for biology · 2026Article
- Using diffusion MRI to relate hippocampal subfield microstructure to delayed verbal memory in cognitively intact individuals at genetic risk for developing Alzheimer's disease.Experimental gerontology · 2026Article
- Functional MRI of the Human Hippocampus at 10.5T: Pushing the Boundaries of Spatial Resolution.bioRxiv : the preprint server for biology · 2026Article
- Quantitative and Morphometric Measures in the Human Hippocampal Tail Using Ex Vivo Imaging Validated With Histology.Hippocampus · 2026Article
- Hippocampal subfield-specific imaging in depression: the translational power of ultra-high field MRI.Translational psychiatry · 2026Review
- Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II.bioRxiv : the preprint server for biology · 2025Article
- Harmonized Protocol for Segmentation of the Hippocampal Tail on High-ResolutionbioRxiv : the preprint server for biology · 2025Article
- Mesoscale connectivity of the human hippocampus and fimbria revealed by ex vivo diffusion MRI.NeuroImage · 2025Article
- Convolutional Neural Networks for the segmentation of hippocampal structures in postmortem MRI scans.Journal of neuroscience methods · 2025Article
- A (sub)field guide to quality control in hippocampal subfield segmentation on high-resolution THuman brain mapping · 2024Review
- Immunohistochemical field parcellation of the human hippocampus along its antero-posterior axis.Brain structure & function · 2024Article
- The prosubiculum in the human hippocampus: A rostrocaudal, feature-driven, and systematic approach.The Journal of comparative neurology · 2024Article
- Neuron collinearity differentiates human hippocampal subregions: a validated deep learning approach.Brain communications · 2024Article
- A (Sub)field Guide to Quality Control in Hippocampal Subfield Segmentation on Highresolution TbioRxiv : the preprint server for biology · 2023Article
- Mapping mesoscale connectivity within the human hippocampus.NeuroImage · 2023Article
- Association of Sleep-Disordered Breathing and Medial Temporal Lobe Atrophy in Cognitively Unimpaired Amyloid-Positive Older Adults.Neurology · 2023Article
- Stereology neuron counts correlate with deep learning estimates in the human hippocampal subregions.Scientific reports · 2023Article
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Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
Abstract
Hippocampal subfield segmentation on in vivo MRI is of great interest for cognition, aging, and disease research. Extant subfield segmentation protocols have been based on neuroanatomical references, but these references often give limited information on anatomical variability. Moreover, there is generally a mismatch between the orientation of the histological sections and the often anisotropic coronal sections on in vivo MRI. To address these issues, we provide a detailed description of hippocampal anatomy using a postmortem dataset containing nine specimens of subjects with and without dementia, which underwent a 9.4 T MRI and histological processing. Postmortem MRI matched the typical orientation of in vivo images and segmentations were generated in MRI space, based on the registered annotated histological sections. We focus on the following topics: the order of appearance of subfields, the location of subfields relative to macroanatomical features, the location of subfields in the uncus and tail and the composition of the dark band, a hypointense layer visible in T2-weighted MRI. Our main findings are that: (a) there is a consistent order of appearance of subfields in the hippocampal head, (b) the composition of subfields is not consistent in the anterior uncus, but more consistent in the posterior uncus, (c) the dark band consists only of the CA-stratum lacunosum moleculare, not the strata moleculare of the dentate gyrus, (d) the subiculum/CA1 border is located at the middle of the width of the hippocampus in the body in coronal plane, but moves in a medial direction from anterior to posterior, and (e) the variable location and composition of subfields in the hippocampal tail can be brought back to a body-like appearance when reslicing the MRI scan following the curvature of the tail. Our findings and this publicly available dataset will hopefully improve anatomical accuracy of future hippocampal subfield segmentation protocols.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.