ArticleHuman brain mapping2020
Understanding the association between psychomotor processing speed and white matter hyperintensity: A comprehensive multi-modality MR imaging study.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The effect of anthocyanins and anthocyanin-rich foods on cognitive function: a meta-analysis of randomized controlled trials.GeroScience · 2026Pooled it
- Tidying up white matter: Neuroplastic transformations in sensorimotor tracts following slackline skill acquisition.Human brain mapping · 2024Trial
- Associations between structural brain alterations and dysfunction across cognitive domains in cerebral small vessel disease: A systematic review and meta-analysis.Neuroimage. Reports · 2026Review
- Associations between cerebral blood transit time, amyloid-β pathology and cognitive decline in non-demented older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Investigating the association of the plasma lipidomic profile with cognitive performance and genetic risk in the PsyCourse study.Translational psychiatry · 2025Article
- Intersection of Brain Complexity, Functional Connectivity, and Neuropsychology: A Systematic Review.Cureus · 2025Review
- Disturbed neurovascular coupling in patients with white matter hyperintensities: potential biomarker for cognitive impairment.Neuroradiology · 2024Article
- Identification of abnormal closed-loop pathways in patients with MRI-negative pharmacoresistant epilepsy.Brain imaging and behavior · 2024Article
- Effects of clamping end-tidal CONMR in biomedicine · 2024Article
- Bridging Reduced Grip Strength and Altered Executive Function: Specific Brain White Matter Structural Changes in Patients with Alzheimer's Disease.Clinical interventions in aging · 2024Article
- Magnetic Resonance Imaging Studies of Neurodegenerative Disease: From Methods to Translational Research.Neuroscience bulletin · 2023Review
- White matter changes underlie hypertension-related cognitive decline in older adults.NeuroImage. Clinical · 2023Review
- Effect of Metabolic Syndrome Risk Factors on Processing Speed and Executive Function in Three Racialized Groups.Journal of Alzheimer's disease : JAD · 2023Article
- Superficial white matter microstructure affects processing speed in cerebral small vessel disease.Human brain mapping · 2022Article
- White Matter Free Water is a Composite Marker of Cerebral Small Vessel Degeneration.Translational stroke research · 2022Article
- The association between cytokines and psychomotor speed in a spectrum of psychotic disorders: A longitudinal study.Brain, behavior, & immunity - health · 2021Article
- Disrupted Structural Brain Connectome Is Related to Cognitive Impairment in Patients With Ischemic Leukoaraiosis.Frontiers in human neuroscience · 2021Article
- Understanding the association between psychomotor processing speed and white matter hyperintensity: A comprehensive multi-modality MR imaging study.Human brain mapping · 2020Article
- Epigenetic age acceleration and cognitive performance over time in older adults.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive processing speed is crucial for human cognition and declines with aging. White matter hyperintensity (WMH), a common sign of WM vascular damage in the elderly, is closely related to slower psychomotor processing speed. In this study, we investigated the association between WMH and psychomotor speed changes through a comprehensive assessment of brain structural and functional features. Multi-modal MRIs were acquired from 60 elderly adults. Psychomotor processing speeds were assessed using the Trail Making Test Part A (TMT-A). Linear regression analyses were performed to assess the associations between TMT-A and brain features, including WMH volumes in five cerebral regions, diffusivity parameters in the major WM tracts, regional gray matter volume, and brain activities across the whole brain. Hierarchical regression analysis was used to demonstrate the contribution of each index to slower psychomotor processing speed. Linear regression analysis demonstrated that WMH volume in the occipital lobe and fractional anisotropy of the forceps major, an occipital association tract, were associated with TMT-A. Besides, resting-state brain activities in the visual cortex connected to the forceps major were associated with TMT-A. Hierarchical regression showed fractional anisotropy of the forceps major and regional brain activities were significant predictors of TMT-A. The occurrence of WMH, combined with the disruption of passing-through fiber integrity and altered functional activities in areas connected by this fiber, are associated with a decline of psychomotor processing speed. While the causal relationship of this WMH-Tract-Function-Behavior link requires further investigation, this study enhances our understanding of these complex mechanisms.
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