Evidence map›Paper›PMID 31675094›Full record

ArticleNeuro-oncology2019

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012-2016.

Quinn T Ostrom, Gino Cioffi, Haley Gittleman, Nirav Patil, Kristin Waite, Carol Kruchko, Jill S Barnholtz-Sloan

2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in Neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1,547 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,547citing papers in PubMed, 8 pooled it
201.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04717739 unknown statusnot on this mapstarted 2021, after this paper: background citation

Use of TTFields in Germany in Routine Clinical Care Study PROgram - Daily Activity, Sleep and Neurocognitive Functioning in Newly Diagnosed Glioblastoma Patients Study

TypeobservationalSponsorNovoCure Ltd.Ran2021 to 2025Enrolled500ConditionsGlioblastomaArmsTTFields
NCT04838782 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Role of Repeat Resection in Recurrent Glioblastoma (4rGBM) Trial: a Randomized Care Trial for Patients With Recurrent GBM

TypeinterventionalSponsorUniversity of AlbertaRan2021 to 2025Enrolled0ConditionsRecurrent Glioblastoma, Glioblastoma - CategoryArmsRepeat Surgical Management of Recurrent GBM
3 · Its place in the literature

Who cites it

1,547 citing papers in PubMed, 8 syntheses or guidelines pooled it, 2,587 citations in OpenAlex.

  1. Pooled it
  2. Successful pre-operative endovascular intraventricular meningioma embolization: a systematic review and pediatric case analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
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  15. Recurrent C19MC-altered embryonal tumors with multilayered rosettes: outcomes of stereotactic radiosurgery.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
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1,487 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Quinn T OstromCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Gino CioffiCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Haley GittlemanCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Nirav PatilCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Kristin WaiteCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Carol KruchkoCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Jill S Barnholtz-SloanCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Central Brain Tumor Registry of the United States · USUniversity School · USBaylor College of Medicine · USCase Western Reserve University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention and National Cancer Institute, is the largest population-based registry focused exclusively on primary brain and other central nervous system (CNS) tumors in the United States (US) and represents the entire US population. This report contains the most up-to-date population-based data on primary brain tumors available and supersedes all previous reports in terms of completeness and accuracy. All rates are age-adjusted using the 2000 US standard population and presented per 100,000 population. The average annual age-adjusted incidence rate (AAAIR) of all malignant and non-malignant brain and other CNS tumors was 23.41 (Malignant AAAIR = 7.08, non-Malignant AAAIR = 16.33). This rate was higher in females compared to males (25.84 versus 20.82), Whites compared to Blacks (23.50 versus 23.34), and non-Hispanics compared to Hispanics (23.84 versus 21.28). The most commonly occurring malignant brain and other CNS tumor was glioblastoma (14.6% of all tumors), and the most common non-malignant tumor was meningioma (37.6% of all tumors). Glioblastoma was more common in males, and meningioma was more common in females. In children and adolescents (age 0-19 years), the incidence rate of all primary brain and other CNS tumors was 6.06. An estimated 86,010 new cases of malignant and non-malignant brain and other CNS tumors are expected to be diagnosed in the US in 2019 (25,510 malignant and 60,490 non-malignant). There were 79,718 deaths attributed to malignant brain and other CNS tumors between 2012 and 2016. This represents an average annual mortality rate of 4.42. The five-year relative survival rate following diagnosis of a malignant brain and other CNS tumor was 35.8%, and the five-year relative survival rate following diagnosis of a non-malignant brain and other CNS tumors was 91.5%.

Indexed as

Data Interpretation, StatisticalAdolescentAdultAgedAged, 80 and overAge FactorsBrain NeoplasmsCentral Nervous System NeoplasmsChildChild, PreschoolFemaleFollow-Up StudiesHumansIncidenceInfantInfant, Newborn

Identifiers

PMID31675094
PMCPMC6823730
OpenAlexW4211132876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.