Evidence map›Paper›PMID 31674909›Full record

ArticleeLife2019

The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier.

Stephen G Brohawn, Weiwei Wang, Annie Handler, Ernest B Campbell, Jürgen R Schwarz, Roderick MacKinnon

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 106 citations in OpenAlex.

  1. A Tac1-Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Structure of the human KNature structural & molecular biology · 2025
    Article
  6. Journal of chemical theory and computation · 2025
    Article
  7. Review
  8. Review
  9. Cannabinoid inhibition of mechanosensitive KbioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. An ankyrin G-binding motif mediates TRAAK periodic localization at axon initial segments of hippocampal pyramidal neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Development of covalent chemogenetic KCell chemical biology · 2024
    Article
  15. Structure of the human KbioRxiv : the preprint server for biology · 2024
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Stephen G Brohawn *Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.ORCID 0000-0001-6768-3406
Weiwei Wang *Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.
Annie HandlerLaboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.
Ernest B CampbellLaboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.
Jürgen R SchwarzInstitute of Molecular Neurogenetics, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-4141-6972
Roderick MacKinnonLaboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.ORCID 0000-0001-7605-4679
Howard Hughes Medical Institute · USUniversität Hamburg · DE

Funding

New approaches to understanding biological force sensationDP2GM123496 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BROHAWN, STEPHEN GRAF · 2016 to 2016
$2.4M
NIGMS NIH HHS DP2 GM123496
6 · The paper itself

Abstract

TRAAK is a membrane tension-activated K

Indexed as

Action PotentialsAnimalsMiceNeuronsPotassium ChannelsRanvier's NodesRatsKcnk4 protein, mouseKcnk4 protein, ratPotassium Channelsmechanosensationmouseneurosciencenode-clampnode of Ranvierratxenopus

Identifiers

PMID31674909
PMCPMC6824864
OpenAlexW2983910499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.