ArticleJournal of the Optical Society of America. A, Optics, image science, and vision2019
Dual-slope method for enhanced depth sensitivity in diffuse optical spectroscopy.
Article in Journal of the Optical Society of America. A, Optics, image science, and vision, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- OptoCENTAL: a standardized, bench-testing platform based on phantoms for validating optical systems aimed at clinical monitoring of the placenta.Journal of biomedical optics · 2026Article
- Advances in fully integrated wearable near-infrared spectroscopy: hardware innovations and biomedical applications.JPhys photonics · 2026Review
- Functional dual-slope frequency-domain near-infrared spectroscopy data interpreted with two- and three-layer models.Biophotonics discovery · 2026Article
- Multi-layer self-calibrated algorithm for transabdominal fetal pulse oximetry: simulation andJPhys photonics · 2026Article
- Article
- Single-distance, phase-only frequency-domain NIRS for vascular oxygenation and tissue metabolism: a Monte Carlo simulation study.Journal of biomedical optics · 2025Article
- Anisotropic light propagation in human brain white matter.Neurophotonics · 2025Article
- Quantification of oxidized and reduced cytochrome-c-oxidase by combining discrete-wavelength time-resolved and broadband continuous-wave near-infrared spectroscopy.Biomedical optics express · 2025Article
- Noninvasive measurements of skeletal muscle hemodynamics using frequency-domain near-infrared spectroscopy: contributions from adipose and bone tissues.Biophotonics discovery · 2025Article
- Broad-Bandwidth Frequency-Domain Near-Infrared Spectroscopy System on a Chip.IEEE sensors journal · 2025Article
- MRI-Guided Near-Infrared Spectroscopic Tomography (MRg-NIRST) Imaging System With Wearable Breast Optical Interface for Breast Cancer Imaging.IEEE transactions on bio-medical engineering · 2025Article
- Frequency-domain instrument with custom ASIC for dual-slope near-infrared spectroscopy.The Review of scientific instruments · 2024Article
- Sensitivity analysis of transabdominal fetal pulse oximetry using MRI-based simulations.Biomedical optics express · 2024Article
- Phase-based structured interrogation frequency-domain near-infrared spectroscopy.Journal of the Optical Society of America. A, Optics, image science, and vision · 2024Article
- Cross-wavelength calibrating method for real-time imaging of tissue optical properties using frequency-domain diffuse optical spectroscopy.Biomedical optics express · 2024Article
- Spatial Sensitivity to Absorption Changes for Various Near-Infrared Spectroscopy Methods: A Compendium Review.Journal of innovative optical health sciences · 2024Article
- Dual-ratio approach to pulse oximetry and the effect of skin tone.Journal of biomedical optics · 2024Article
- Single-distance and dual-slope frequency-domain near-infrared spectroscopy to assess skeletal muscle hemodynamics.Journal of biomedical optics · 2023Article
- Depth-selective method for time-domain diffuse reflectance measurements: validation study of the dual subtraction technique.Biomedical optics express · 2023Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Using diffusion theory, we show that a dual-slope method is more effective than single-slope methods or single-distance methods at enhancing sensitivity to deeper tissue. The dual-slope method requires a minimum of two sources and two detectors arranged in specially configured arrays. In particular, we present diffusion theory results for a symmetrical linear array of two sources (separated by 55 mm) that sandwich two detectors (separated by 15 mm), for which dual slopes achieve maximal sensitivity at a depth of about 5 mm for direct current (DC) intensity (as measured in continuous-wave spectroscopy) and 11 mm for phase (as measured in frequency-domain spectroscopy) under typical values of the tissue optical properties (absorption coefficient: ∼0.01
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.