Evidence map›Paper›PMID 31674060›Full record

Trial reportMovement disorders : official journal of the Movement Disorder Society2020

Melatonin for rapid eye movement sleep behavior disorder in Parkinson's disease: A randomised controlled trial.

Moran Gilat, Alessandra Coeytaux Jackson, Nathaniel S Marshall, Deborah Hammond, Anna E Mullins, Julie M Hall, Bernard A M Fang, Brendon J Yee, Keith K H Wong, Ron R Grunstein and 1 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Movement disorders : official journal of the Movement Disorder Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 7 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 7 syntheses or guidelines pooled it, 136 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Exploring the role of melatonin in managing sleep and motor symptoms in Parkinson's disease: a pooled analysis of double-blinded randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  4. Management of REM sleep behavior disorder: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. A case of prazosin in treatment of rapid eye movement sleep behavior disorder.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Moran GilatWoolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
Alessandra Coeytaux JacksonWoolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
Nathaniel S MarshallWoolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
Deborah HammondForeFront Parkinson's Disease Research Clinic, Brain and Mind Centre, The University of Sydney, Sydney, Australia.
Anna E MullinsWoolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
Julie M HallForeFront Parkinson's Disease Research Clinic, Brain and Mind Centre, The University of Sydney, Sydney, Australia.
Bernard A M FangWoolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
Brendon J YeeWoolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
Keith K H WongWoolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
Ron R GrunsteinWoolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
Simon J G LewisWoolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
Woolcock Institute of Medical Research · AUUniversity of Sydney · AUMIND Research Institute · USNeuroelectronics Research Flanders · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMelatonin may reduce REM-sleep behavior disorder (RBD) symptoms in Parkinson's disease (PD), though robust clinical trials are lacking.

objectiveTo assess the efficacy of prolonged-release (PR) melatonin for RBD in PD.

methodsRandomized, double-blind, placebo-controlled, parallel-group trial with an 8-week intervention and 4-week observation pre- and postintervention (ACTRN12613000648729). Thirty PD patients with rapid eye movement sleep behavior disorder were randomized to 4 mg of prolonged-release melatonin (Circadin) or matched placebo, ingested orally once-daily before bedtime. Primary outcome was the aggregate of rapid eye movement sleep behavior disorder incidents averaged over weeks 5 to 8 of treatment captured by a weekly diary. Data were included in a mixed-model analysis of variance (n = 15 per group).

resultsNo differences between groups at the primary endpoint (3.4 events/week melatonin vs. 3.6 placebo; difference, 0.2; 95% confidence interval = -3.2 to 3.6; P = 0.92). Adverse events included mild headaches, fatigue, and morning sleepiness (n = 4 melatonin; n = 5 placebo).

conclusionProlonged-release melatonin 4 mg did not reduce rapid eye movement sleep behavior disorder in PD. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Indexed as

AgedClonazepamDouble-Blind MethodEye MovementsFatigueFemaleHumansMaleMelatoninMiddle AgedParkinson DiseasePolysomnographyREM Sleep Behavior DisorderClonazepamMelatoninmelatoninParkinson's diseaserandomized controlled trialREM sleep behavior disordersleep disorders

Identifiers

PMID31674060
PMCPMC7027846
OpenAlexW2986540808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.