ArticleThe Journal of pathology2020
Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation.
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Article in The Journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Cancer-Associated Fibroblasts in Prostate Cancer: Unraveling Mechanisms and Therapeutic Implications.Oncology research · 2026Review
- Effect of pulmonary arterial hypertension on the morphology and antioxidant defence of the ventral prostate of sedentary and exercised rats.International journal of experimental pathology · 2025Article
- Mechanisms of prostatic inflammation-mediated male lower urinary tract symptoms.American journal of clinical and experimental urology · 2025Review
- Impact of Renin-Angiotensin System Inhibitors on Disease Characteristics in Patients with Localized Prostate Cancer Treated with Radical Prostatectomy: A European Association of Urology Young Academic Urologists Prostate Cancer Working Group Multi-institutional Study.European urology open science · 2024Article
- Deciphering the Tumor Microenvironment in Prostate Cancer: A Focus on the Stromal Component.Cancers · 2024Review
- Identification of collagen subtypes of gastric cancer for distinguishing patient prognosis and therapeutic response.Cancer innovation · 2024Article
- Aberrant activation of TGF-β/ROCK1 enhances stemness during prostatic stromal hyperplasia.Cell communication and signaling : CCS · 2024Article
- Inhibition of phosphatidylinositol 3-kinase catalytic subunit alpha by miR-203a-3p reduces hypertrophic scar formation via phosphatidylinositol 3-kinase/AKT/mTOR signaling pathway.Burns & trauma · 2024Article
- Lack of expression of miR-29a/b1 impairs bladder function in male mice.Disease models & mechanisms · 2023Article
- Cancer-Associated Fibroblast Heterogeneity, Activation and Function: Implications for Prostate Cancer.Biomolecules · 2022Review
- The Pro-Fibrotic Response to Lens Injury Is Signaled in a PI3K Isoform-Specific Manner.Biomolecules · 2022Article
- Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research.Toxics · 2022Review
- Different feeding strategies can affect growth performance and rumen functions in Gangba sheep as revealed by integrated transcriptome and microbiome analyses.Frontiers in microbiology · 2022Article
- Cromolyn platform suppresses fibrosis and inflammation, promotes microglial phagocytosis and neurite outgrowth.Scientific reports · 2021Article
- Integrative analysis of miRNA-mRNA expression profiles in esophageal fibrosis after ESD.Experimental and therapeutic medicine · 2021Article
- The Effects of Resveratrol on Prostate Cancer through Targeting the Tumor Microenvironment.Journal of xenobiotics · 2021Review
- Oligometastatic Prostate Adenocarcinoma. Clinical-Pathologic Study of a Histologically Under-Recognized Prostate Cancer.Journal of personalized medicine · 2020Article
- Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Kyle A WegnerMolecular and Environmental Toxicology Center, University of Wisconsin-Madison, Madison, WI, USA.
Brett R MuellerUniversity of Wisconsin-Madison/UMASS Boston George M. O'Brien Center for Benign Urologic Research, Madison, WI, USA.
Christopher J UnterbergerUniversity of Wisconsin-Madison/UMASS Boston George M. O'Brien Center for Benign Urologic Research, Madison, WI, USA.
Enrique J AvilaUniversity of Wisconsin-Madison/UMASS Boston George M. O'Brien Center for Benign Urologic Research, Madison, WI, USA.
Hannah RuettenDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Anne E TurcoMolecular and Environmental Toxicology Center, University of Wisconsin-Madison, Madison, WI, USA.
Steven R OakesDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Nicholas M GirardiDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Richard B HalbergDepartment of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA.
Steven M SwansonSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.
Paul C MarkerUniversity of Wisconsin-Madison/UMASS Boston George M. O'Brien Center for Benign Urologic Research, Madison, WI, USA.
Chad M VezinaMolecular and Environmental Toxicology Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-7058-5399
University of Wisconsin System · USUniversity of Wisconsin–Madison · US
Funding
Role of Beta-Catenin in Urinary DysfunctionU54DK104310 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI MACOSKA, JILL A., MARKER, PAUL C · 2014 to 2023
$12.8MMolecular & Environmental Toxicology Pre-& Postdoctoral Training ProgramT32ES007015 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTOPHER A BRADFIELD · 1985 to 2026
$11.5MNRSA Training CoreTL1TR002375 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Vivek Prabhakaran · 2017 to 2026
$8.4MREPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF DIOXINR01ES001332 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI PETERSON, RICHARD EUGENE, VEZINA, CHAD M. · 1985 to 2021
$5.3MMagi2 in aggressive prostate cancerR21CA195313 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI MARKER, PAUL C · 2016 to 2017
$357kProstate inflammation increases collagen and voiding dysfunctionF30DK122686 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI RUETTEN, HANNAH MARGARET · 2019 to 2022
$157kTCDD Reprograms Prostate Stroma and Causes Fibrosis to Induce Urinary DysfunctionF31ES028594 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI WEGNER, KYLE ALLEN · 2018 to 2019
$54kDevelopmental origins of prostate-related urinary dysfunction in adult males: TCDD exposure increases prostatic noradrenergic innervation and smooth muscle contractionF31ES030968 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI TURCO, ANNE · 2020 to 2021
$42kNCATS NIH HHS TL1 TR002375NCI NIH HHS R21 CA195313NIDDK NIH HHS F30 DK122686NIDDK NIH HHS U54 DK104310NIEHS NIH HHS F31 ES028594NIEHS NIH HHS F31 ES030968NIEHS NIH HHS R01 ES001332NIEHS NIH HHS T32 ES007015NIH HHS CA195313NIH HHS F30DK122686NIH HHS F31ES028594NIH HHS R01ES001332NIH HHS T32ES007015NIH HHS TL1TR002375NIH HHS U54DK104310NIH HHS U54DK104310S1
Abstract
We genetically engineered expression of an activated form of P110 alpha, the catalytic subunit of PI3K, in mouse prostate epithelium to create a mouse model of direct PI3K activation (Pbsn-cre4Prb;PI3K
Indexed as
AgingAnimalsClass I Phosphatidylinositol 3-KinasesCollagenDisease Models, AnimalDisease ProgressionEpitheliumMaleMice, Mutant StrainsPhosphorylationProstateProstatic HyperplasiaProstatic Intraepithelial NeoplasiaProstatic NeoplasmsSignal TransductionSmad2 Protein1-phosphatidylinositol 3-kinase p110 subunit, mouseClass I Phosphatidylinositol 3-KinasesCollagenSmad2 ProteinSmad2 protein, mouseTransforming Growth Factor betacancercollagenfibrosismouse modelPIK3CAprostatestroma
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