ReviewAdvances in therapy2020
Dyspnea in COPD: New Mechanistic Insights and Management Implications.
Review in Advances in therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 103 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Diaphragm and Abdominal Muscle Training on Pulmonary Function Testing and Dyspnea Among Chronic Obstructive Pulmonary Disease Patients.
Efficacy of Different Osteopathic Manipulative Techniques Combined With Diaphragmatic Release in Patients With Chronic Obstructive Pulmonary Disease
Who cites it
103 citing papers in PubMed, 6 syntheses or guidelines pooled it, 233 citations in OpenAlex.
- Respiratory muscle endurance training among patients with chronic diseases: A systematic review of available evidence.Experimental physiology · 2026Pooled it
- Barriers and enablers to centre-based pulmonary rehabilitation for patients with chronic obstructive pulmonary disease in low- and middle-income countries: a systematic review.Journal of global health · 2025Pooled it
- A meta-analysis of the effects of long-term oxygen therapy combined with exercise rehabilitation on exercise capacity, cardiopulmonary function, and quality of life in patients with COPD.Frontiers in medicine · 2025Pooled it
- Supplemental oxygen for symptomatic relief in people with serious respiratory illness: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Multicomponent services for symptoms in serious respiratory illness: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Opioids for the palliation of symptoms in people with serious respiratory illness: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Singing as training modality within pulmonary rehabilitation for COPD patients may enhance diaphragmatic function: a pilot RCT exploring impact on diaphragmatic mobility and thickness.Frontiers in physiology · 2026Trial
- Trial
- Trial
- Effectiveness of message framing on pulmonary rehabilitation behavior for lung cancer surgery patients: Randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Effect of Eccentric Cycling on Oxygen Uptake and Hemodynamics in Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Crossover Trial.Respiration; international review of thoracic diseases · 2025Trial
- Automated Oxygen Administration Alleviates Dyspnea in Patients Admitted with Acute Exacerbation of COPD: A Randomized Controlled Trial.International journal of chronic obstructive pulmonary disease · 2023Trial
- Development and Internal Validation of a Prediction Model Incorporating Respiratory Muscle Function for CAT Score Deterioration in Stable COPD.The clinical respiratory journal · 2026Article
- Short-term inspiratory muscle training, aerobic exercise, and detraining in women with COPD: a randomized controlled trial.BMC sports science, medicine & rehabilitation · 2026Article
- Beyond Mobility: Are We Capturing the True Rehabilitation Needs of Patients with Respiratory Disease?Journal of general internal medicine · 2026Article
- Objective dyspnea measurement in real time using a forehead wearable and artificial intelligence.NPJ primary care respiratory medicine · 2026Article
- Article
- A Brief History of COPD: As Told by Some of Its Senior Scientists and Clinicians.Journal of clinical medicine · 2026Review
- Effects of Pulmonary Rehabilitation on Dyspnea, Quality of Life and Cognitive Function in COPD: A Systematic Review.Journal of clinical medicine · 2026Review
- Multifactorial Determinants of Refractory Breathlessness in COPD: Development of the Refractory Breathlessness Score for Risk Stratification.International journal of chronic obstructive pulmonary disease · 2026Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Dyspnea is the most common symptom experienced by patients with chronic obstructive pulmonary disease (COPD). To avoid exertional dyspnea, many patients adopt a sedentary lifestyle which predictably leads to extensive skeletal muscle deconditioning, social isolation, and its negative psychological sequalae. This "dyspnea spiral" is well documented and it is no surprise that alleviation of this distressing symptom has become a key objective highlighted across COPD guidelines. In reality, this important goal is often difficult to achieve, and successful symptom management awaits a clearer understanding of the underlying mechanisms of dyspnea and how these can be therapeutically manipulated for the patients' benefit. Current theoretical constructs of the origins of activity-related dyspnea generally endorse the classical demand-capacity imbalance theory. Thus, it is believed that disruption of the normally harmonious relationship between inspiratory neural drive (IND) to breathe and the simultaneous dynamic response of the respiratory system fundamentally shapes the expression of respiratory discomfort in COPD. Sadly, the symptom of dyspnea cannot be eliminated in patients with advanced COPD with relatively fixed pathophysiological impairment. However, there is evidence that effective symptom palliation is possible for many. Interventions that reduce IND, without compromising alveolar ventilation (V
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.