ArticleBreast cancer research and treatment2020
Association of depression and anxiety disorder with the risk of mortality in breast cancer: A National Health Insurance Service study in Korea.
Article in Breast cancer research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 6 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Depression increases cancer mortality by 23-83%: a meta-analysis of 65 studies across five major cancer types.GeroScience · 2026Pooled it
- Systematic review on the effectiveness of mobile health applications on mental health of breast cancer survivors.Journal of cancer survivorship : research and practice · 2025Pooled it
- Depression, anxiety and associated factors among cancer patients in Africa; a systematic review and meta-analysis study.BMC psychiatry · 2024Pooled it
- Anxiety and depression among cancer patients in Ethiopia: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Factors influencing depressive symptoms in Chinese female breast cancer patients: a meta-analysis.Frontiers in psychology · 2024Pooled it
- Prognostic value of depression and anxiety on breast cancer recurrence and mortality: a systematic review and meta-analysis of 282,203 patients.Molecular psychiatry · 2020Pooled it
- Association between antidepressant exposure and prognosis in breast cancer: A systematic review and meta-analysis.Oncology letters · 2026Article
- Anxiety and screening attitudes in breast cancer patients and their first-degree relatives: A comparative pilot study.Turkish journal of surgery · 2026Article
- Depression and long-term mortality among 5-year breast cancer survivors in Korea: a retrospective population-based cohort study.Scientific reports · 2026Article
- The effects of emotional distress on the postoperative survival and progression in patients with breast cancer: a prospective observational study.World journal of surgical oncology · 2025Observational
- Article
- All-cause and cause-specific mortality in people with depression: a large-scale systematic review and meta-analysis of relative risk and aggravating or attenuating factors, including antidepressant treatment.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Senkyunolide H reverses depression-induced breast cancer progression by regulating CXCR2.Natural products and bioprospecting · 2025Article
- Impact of Depression and/or Anxiety on Mortality in Women with Gynecologic Cancers: A Nationwide Retrospective Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- Plasma vitamin D binding protein as the potential predictor of depressive disorder risk in breast cancer patients.Scientific reports · 2025Article
- Article
- Association between the Chinese Dietary Balance Index-based dietary quality and depressive symptoms in breast cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Evaluating the Effectiveness of a Mobile App for Breast Cancer Self-Management on Self-Efficacy: Nonrandomized Intervention Trial.JMIR mHealth and uHealth · 2025Article
- New highlights in cancer and depression multimorbidity: a scoping systematic review.Frontiers in oncology · 2025Review
- Article
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Authors and funding
10 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo examine whether depression, anxiety disorder, and their co-occurrence would increase the risk of mortality in patients with breast cancer, and whether antidepressant treatment would reduce the same.
methodsData were retrieved from the database of the Korean National Health Insurance Service. Of 145,251 patients diagnosed with breast cancer between 2007 and 2014, 20,870 patients diagnosed with depression or anxiety disorder one year before breast cancer diagnosis were excluded. Thus, data of 124,381 patients were included in this study.
resultsDepression and anxiety disorder were associated with an increased risk of mortality [Hazard Ratio (HR) 1.26, 95% CI 1.18-1.36; HR 1.14, 95% CI 1.08-1.22, respectively] and their co-occurrence further increased the risk (HR = 1.38, 95% CI 1.24-1.54). Antidepressant treatment was related to a reduced risk of mortality. Compared to patients without any psychiatric comorbidity with no antidepressant treatment, the mortality risk increased in patients with either psychiatric comorbidity or both, but the risk seemed to attenuate with antidepressant treatments.
conclusionThe current findings suggest that psychiatric comorbidities are markers of increased mortality risk in patients with breast cancer, and antidepressant treatment may attenuate the risk. This underscores the need for screening and treating depression and anxiety disorders to improve survival in patients with breast cancer.
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