Evidence map›Paper›PMID 31673789›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

Fabian Haupt, Lotte Dijkstra, Ian Alberts, Christos Sachpekidis, Viktor Fech, Silvan Boxler, Tobias Gross, Tim Holland-Letz, Helle D Zacho, Uwe Haberkorn and 3 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07357259 (Delayed Pelvic Imaging With [68]Ga-PSMA PET/CT in a Patient With High-risk Prostate Cancer.), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07357259 narecruitingnot on this mapstarted 2025, after this paper: background citation

Delayed Pelvic Imaging With [68]Ga-PSMA PET/CT in a Patient With High-risk Prostate Cancer.

TypeinterventionalSponsorIRCCS Azienda Ospedaliero-Universitaria di BolognaRan2025 to 2027Enrolled244ConditionsHigh-risk Prostate CancerArmsIntervention Group
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Furosemide Reduces Radionuclide Activity in the Bladder inDiagnostics (Basel, Switzerland) · 2025
    Article
  5. Diagnostic value of dual-time pointAbdominal radiology (New York) · 2024
    Article
  6. Combined whole-body dynamic and static PET/CT with low-dose [European journal of nuclear medicine and molecular imaging · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Hybrid imaging with [Cancer imaging : the official publication of the International Cancer Imaging Society · 2022
    Article
  11. Article
  12. Clinical insignificance of [European journal of nuclear medicine and molecular imaging · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Dual-Time Point [Cancers · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Fabian HauptDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Lotte DijkstraDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Ian AlbertsDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Christos SachpekidisDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Viktor FechDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Silvan BoxlerDepartment of Urology, Bern University Hospital, Bern, Switzerland.
Tobias GrossDepartment of Urology, Bern University Hospital, Bern, Switzerland.
Tim Holland-LetzDepartment of Biostatistics, German Cancer Research Center, Heidelberg, Germany.
Helle D ZachoDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Uwe HaberkornDepartment of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Kambiz RahbarDepartment of Nuclear Medicine, University Hospital Münster, Münster, Germany.
Axel RomingerDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Ali Afshar-OromiehDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. a.afshar@gmx.de.ORCID 0000-0002-4492-4243
University of Bern · CHUniversity Hospital of Bern · CHAalborg University · DKGerman Cancer Research Center · DEHeidelberg University · DEUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose

methodsIn 2017, we used the following scanning protocol for

resultsBoth tumor contrast and tracer uptake were significantly (p < 0.001) higher in the novel protocol. Although statistically not significant, the rates of pathologic scans were also higher in the modified protocol: 76.3% vs. 68.8% for all PSA values including 38.9% vs. 25.0% for PSA < 0.5 ng/ml and 60.0% vs. 56.7% for PSA > 0.5-≤ 2.0 ng/ml. Average SUVmean of the urinary bladder was significantly (p < 0.001) lower with the modified protocol.

conclusionsThe modified protocol, which includes a combination of delayed image acquisition at 1.5 h p.i., hydration, and furosemide resulted in higher tumor contrast and seems to have the potential to increase the rates of pathological scans, especially at low PSA levels.

Indexed as

Positron Emission Tomography Computed TomographyProstatic NeoplasmsEdetic AcidGallium IsotopesGallium RadioisotopesHumansMaleNeoplasm Recurrence, LocalOligopeptidesRetrospective StudiesEdetic Acidgallium 68 PSMA-11Gallium IsotopesGallium RadioisotopesOligopeptides68Ga-PSMA-11FurosemideHydrationPET/CTProstate cancerProstate-specific membrane antigenProtocolPSMA

Identifiers

PMID31673789
OpenAlexW2984398807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.