Evidence map›Paper›PMID 31673787›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

Suboptimal validity of amyloid imaging-based diagnosis and management of Alzheimer's disease: why it is time to abandon the approach.

Abass Alavi, Jorge R Barrio, Thomas J Werner, Mohsen Khosravi, Andrew Newberg, Poul Flemming Høilund-Carlsen

Abstract readEditorial
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Alzheimer's Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?International journal of molecular sciences · 2024
    Review
  5. Review
  6. Potential of PET/CT in assessing dementias with emphasis on cerebrovascular disorders.European journal of nuclear medicine and molecular imaging · 2020
    Article
  7. Proven validity and management impact of amyloid imaging in Alzheimer's disease-repetita juvant.European journal of nuclear medicine and molecular imaging · 2020
    Article
  8. The relationship ofJournal of Alzheimer's disease reports
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Abass AlaviDepartment of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA. abass.alavi@uphs.upenn.edu.
Jorge R BarrioDavid Geffen UCLA School of Medicine, Los Angeles, CA, 90095, USA.
Thomas J WernerDepartment of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Mohsen KhosraviDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA, USA.
Andrew NewbergDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA, USA.
Poul Flemming Høilund-CarlsenDepartment of Nuclear Medicine, Odense University Hospital, Odense, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseAmyloidAmyloid beta-PeptidesBrainHumansPositron-Emission TomographyAmyloidAmyloid beta-Peptides

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.