Evidence map›Paper›PMID 31673770›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2019

Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation.

Justin T Avery, Rachel V Jimenez, Joseph L Blake, Tyler T Wright, Beatriz Leόn-Ruiz, Trenton R Schoeb, Alexander J Szalai, Daniel C Bullard

Open access · hybridAbstract read
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

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  8. Bioinformatics-Based Study to Investigate Potential Differentially Expressed Genes and miRNAs in Pediatric Sepsis.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Justin T AveryDepartment of Genetics, University of Alabama at Birmingham, 1700 University Blvd., Birmingham, AL, 35294-0013, USA.
Rachel V JimenezDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Joseph L BlakeDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Tyler T WrightDepartment of Clinical and Health Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
Beatriz Leόn-RuizDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Trenton R SchoebDepartment of Genetics, University of Alabama at Birmingham, 1700 University Blvd., Birmingham, AL, 35294-0013, USA.
Alexander J SzalaiDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Daniel C BullardDepartment of Genetics, University of Alabama at Birmingham, 1700 University Blvd., Birmingham, AL, 35294-0013, USA. dcbullard@uab.edu.ORCID 0000-0003-3500-1057
University of Alabama at Birmingham · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
UAB Recessive PKD Research and Translational Core CenterP30DK074038 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 2005 to 2019
$16.6M
ROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5M
Regulation of T cell responses to allergens and environmental microbesR01AI116584 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUND, FRANCES E. · 2015 to 2024
$4.1M
C-reactive protein in acute kidney injuryR01DK099092 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SZALAI, ALEXANDER J · 2014 to 2017
$1.3M
Impact of SLE-Associated ITGAM Variants on Dendritic Cell FunctionR21AR069295 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BULLARD, DANIEL C, SZALAI, ALEXANDER J · 2016 to 2017
$351k
NCI NIH HHS P30 CA013148NIAID NIH HHS R01 AI116584NIAMS NIH HHS P30 AR048311NIAMS NIH HHS R21 AR069295NIDDK NIH HHS P30 DK074038NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK099092NIH HHS 1R01DK099092NIH HHS 1R21AR069295
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) and functional genomic analyses have implicated several ITGAM (CD11b) single-nucleotide polymorphisms (SNPs) in the development of SLE and other disorders. ITGAM encodes the α

Indexed as

Polymorphism, Single NucleotideAllelesAmino Acid SubstitutionAnimalsCD11b AntigenCell ProliferationDendritic CellsFemaleGenome-Wide Association StudyGenotypeMaleMiceMice, Inbred C57BLT-LymphocytesCD11b AntigenItgam protein, mouse

Identifiers

PMID31673770
PMCPMC6842653
OpenAlexW2982498671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.