ArticleNeuroradiology2020
Ultra-low-dose multiphase CT angiography derived from CT perfusion data in patients with middle cerebral artery stenosis.
Article in Neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Clinical application of third-generation dual-source CT-based dynamic imaging reconstruction for pulmonary embolism imaging.Journal of cardiothoracic surgery · 2025Trial
- Balancing Radiation Dose and Image Quality: Protocol Optimization for Mobile Head CT in Neurointensive Care Unit Patients.Diagnostics (Basel, Switzerland) · 2026Article
- Optimization of image quality and diagnostic accuracy for vascular stenosis in computed tomography perfusion-reconstructed cerebral computed tomography angiography using deep learning reconstruction.Journal of clinical imaging science · 2026Article
- Development and validation of a prognostic nomogram incorporating automated collateral score and computed tomography perfusion parameters for patients with acute ischemic stroke undergoing endovascular thrombectomy.Quantitative imaging in medicine and surgery · 2025Article
- Comparison of objective quality parameters between CTA and CTP angiographic reconstructions in ischemic stroke patients.European journal of radiology open · 2025Article
- Optimizing Radiation Dose and Image Quality in Stroke CT Protocols: Proposed Diagnostic Reference Levels for Multiphase CT Angiography and Perfusion Imaging.Diagnostics (Basel, Switzerland) · 2024Article
- Association of atherosclerotic plaque features with collateral circulation status in elderly patients with chronic carotid stenosis.Journal of geriatric cardiology : JGC · 2020Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeComputed tomography (CT) perfusion (CTP) source images contain both brain perfusion and cerebrovascular information, and may allow a dynamic assessment of collaterals. The purpose of the study was to compare the image quality and the collaterals identified on multiphase CT angiography (CTA) derived from CTP datasets (hereafter called CTPA) reconstructed with iterative model reconstruction (IMR) algorithm in patients with middle cerebral artery (MCA) steno-occlusion with those of routine CTA.
methodsConsecutive patients with a unilateral MCA steno-occlusion underwent non-contrast CT (NCCT), CTP, and CTA. CTPA images were reconstructed from CTP datasets. The vascular attenuation, image noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) of routine CTA and CTPA were measured and analyzed by Student's t test. Subjective image quality and collaterals were scored and compared using the Wilcoxon signed-rank test.
resultsFifty-eight patients (mean age 61.7 years, 78% males, median National Institutes of Health Stroke Scale score = 12) were included. The effective radiation dose of CTP was 1.28 mSv. The vascular attenuation, SNR, CNR, and the image quality of CTPA were considerably higher than that of CTA (all, p < 0.001). Collaterals were rated higher on CTPA compared with CTA (1.79 ± 0.64 vs. 1.22 ± 0.84, p < 0.001). Fifty-three percent of patients with poor collaterals assessed on single-phase CTA had good collaterals on CTPA.
conclusionCTPA derived from CTP datasets reconstructed with IMR algorithm offers image quality comparable to routine CTA and provides time-resolved evaluation of collaterals in patients with MCA ischemic disease.
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