Evidence map›Paper›PMID 31673719›Full record

ArticleSkeletal radiology2020

Lumbar facet joint subchondral bone density in low back pain and asymptomatic subjects.

Chien-Chou Pan, Peter Simon, Alejandro A Espinoza Orías, Ryota Takatori, Howard S An, Gunnar B J Andersson, Nozomu Inoue

Open access · greenAbstract read
In one paragraph

Article in Skeletal radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  5. Level dependent alterations in human facet cartilage mechanics and bone morphometry with spine degeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 3 countries.

Chien-Chou PanDepartment of Orthopedic Surgery, Rush University Medical Center, 1611 W Harrison Street, Suite 201 Orthopedic Building, Chicago, IL, 60612, USA.ORCID http://orcid.org/0000-0002-9902-2474
Peter SimonDepartment of Orthopedic Surgery, Rush University Medical Center, 1611 W Harrison Street, Suite 201 Orthopedic Building, Chicago, IL, 60612, USA.ORCID http://orcid.org/0000-0001-8357-0268
Alejandro A Espinoza OríasDepartment of Orthopedic Surgery, Rush University Medical Center, 1611 W Harrison Street, Suite 201 Orthopedic Building, Chicago, IL, 60612, USA.ORCID http://orcid.org/0000-0002-3792-515X
Ryota TakatoriDepartment of Orthopedic Surgery, Rush University Medical Center, 1611 W Harrison Street, Suite 201 Orthopedic Building, Chicago, IL, 60612, USA.ORCID http://orcid.org/0000-0002-0867-3918
Howard S AnDepartment of Orthopedic Surgery, Rush University Medical Center, 1611 W Harrison Street, Suite 201 Orthopedic Building, Chicago, IL, 60612, USA.
Gunnar B J AnderssonDepartment of Orthopedic Surgery, Rush University Medical Center, 1611 W Harrison Street, Suite 201 Orthopedic Building, Chicago, IL, 60612, USA.
Nozomu InoueDepartment of Orthopedic Surgery, Rush University Medical Center, 1611 W Harrison Street, Suite 201 Orthopedic Building, Chicago, IL, 60612, USA. nozomu_inoue@rush.edu.ORCID http://orcid.org/0000-0002-6418-713X
Rush University Medical Center · US

Funding

Segmental spine motion of the lumbar spineP01AR048152 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI AN, HOWARD S · 2001 to 2010
$13.7M
Novel Analytical Tools for 3 Dimensional Imaging Studies on Spinal ManipulationR01AT006692 · NCCIH · RUSH UNIVERSITY MEDICAL CENTER · PI INOUE, NOZOMU · 2012 to 2016
$1.8M
NCCIH NIH HHS R01 AT006692NIAMS NIH HHS P01 AR048152NIAMS NIH HHS P01 AR48152
6 · The paper itself

Abstract

objectiveTo report in vivo measurements of lumbar facet joint subchondral bone mineral density used in the description of facet joint loading patterns and to interrogate if low back pain is associated with changes in subchondral bone mineral density. MATERIALS AND

methodsIn vivo measurements of lumbar facet joint subchondral bone mineral density (L1/2 to L5/S1) in Hounsfield units were performed on 89 volunteers (56 controls and 33 with low back pain) by computed tomography osteoabsorptiometry at subchondral regions between 1.5 mm and 2.5 mm below the joint surface. The facet surface was divided into five topographic zones: cranial, lateral, caudal, medial, and central.

resultsWe analyzed 1780 facet joint surfaces. Facets were denser (p < 0.0001) both in superior facets and in low back pain subjects (p < 0.0001). For the entire cohort, the facet center zone subchondral bone mineral density was higher (p < 0.0001) than that of the peripheral zones. The analyses indicate that subchondral bone mineral density is highest in patients with low back pain, the superior facets, and the center zone of the facets.

conclusionsSubchondral bone mineral density is thought to reflect cumulative, long-term distribution of stress acting on a joint. This work shows that higher subchondral bone mineral density values in the center zone indicate predominant stress transmission through the center of the facet joints. Finally, the greater subchondral bone mineral density in patients with low back pain may reflect both increased load bearing by the facets secondary to disc degeneration and misdistribution of loading within the joint.

Indexed as

AdultBone DensityCohort StudiesFemaleHumansLow Back PainLumbar VertebraeMaleMiddle AgedTomography, X-Ray ComputedYoung AdultZygapophyseal JointLow back painLumbar facet jointSubchondral bone density

Identifiers

PMID31673719
PMCPMC7024659
OpenAlexW2982938034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.