ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019
Measuring longitudinal cognition: Individual tests versus composites.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
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Who cites it
109 citing papers in PubMed.
- Psychological characteristics and functional abilities in older adults with subjective cognitive complaints: A potential new target for early intervention.International psychogeriatrics · 2026Trial
- Integrating home-based video teleneuropsychology into neurology clinical practice: Utility in patients with suspected typical or atypical Alzheimer's disease presentations.The Clinical neuropsychologist · 2025Trial
- Baseline cognition and demographic, lifestyle, and cardiovascular risk factors in US POINTER.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Aerobic exercise training and neurocognitive function in cognitively normal older adults: A one-year randomized controlled trial.Journal of internal medicine · 2022Trial
- Trial
- Data‑driven cognitive composites predict Aβ‑related decline and progression to MCI: the ADOPIC study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multi-omics integration of transcriptomics and metabolomics with machine learning uncovers novel risk factors for Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2026Article
- Joint trajectories of brain atrophy, white matter hyperintensities and cognition quantify brain maintenance.Nature communications · 2026Article
- Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology.Nature communications · 2026Article
- Telomere Length and Cognitive Function Among Middle-Aged and Older Participants From Communities Underrepresented in Aging Research: A Preliminary Study.Journal of aging and health · 2026Article
- Neuroanatomical correlates of neuropsychological dysfunction in pediatric pharmacoresistant epilepsy due to focal cortical dysplasia type II.Epilepsia open · 2026Article
- Differential associations between subjective and objective physical activity and memory across adulthood: a specification curve analysis.Scientific reports · 2026Article
- Prevalence of dementia and mild cognitive impairment in the Mexican population: evidence from Mex-Cog, a harmonized cognitive assessment protocol study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Enhanced sensitivity to plasma p-tau217 with proper names recall in the preclinical Alzheimer's cognitive composite.Brain communications · 2026Article
- Redefining cognitive testing: the impact of cognitive reserve and sex from early to late adulthood.Frontiers in psychology · 2026Article
- Sarcopenic Obesity and Longitudinal Trajectories on Cognitive Performance and Subtle Cognitive Impairment Over 6 Years in Older Adults.Journal of cachexia, sarcopenia and muscle · 2025Article
- Linking silent pause locations in speech to amyloid and tau deposition in cognitively unimpaired individuals.Journal of Alzheimer's disease : JAD · 2025Article
- Predicting cognitive decline with amyloid-PET, plasma p-tau217, Aβ42/40, and p-tau217/Aβ42 in a community-based cohort - relevance for clinical trial enrollment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Tau mediates the impact of amyloid and vascular disease burden on the trajectory of clinical symptoms.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Regularized regression outperforms trees for predicting cognitive function in the Health and Retirement Study.Machine learning with applications · 2025Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
introductionLongitudinal cohort studies of cognitive aging must confront several sources of within-person variability in scores. In this article, we compare several neuropsychological measures in terms of longitudinal error variance and relationships with biomarker-assessed brain amyloidosis (Aβ).
methodsAnalyses used data from the Wisconsin Registry for Alzheimer's Prevention. We quantified within-person longitudinal variability and age-related trajectories for several global and domain-specific composites and their constituent scores. For a subset with cerebrospinal fluid or amyloid positron emission tomography measures, we examined how Aβ modified cognitive trajectories.
resultsGlobal and theoretically derived composites exhibited lower intraindividual variability and stronger age × Aβ interactions than did empirically derived composites or raw scores from single tests. For example, the theoretical executive function outperformed other executive function scores on both metrics. DISCUSSION: These results reinforce the need for careful selection of cognitive outcomes in study design, and support the emerging consensus favoring composites over single-test measures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.