ArticleTurkish journal of obstetrics and gynecology2019
Effects of vitamin D supplementation on follicular development, gonadotropins and sex hormone concentrations, and insulin resistance in induced polycystic ovary syndrome.
Article in Turkish journal of obstetrics and gynecology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Effects of Vitamin D Supplementation on Surrogate Markers of Fertility in PCOS Women: A Randomized Controlled Trial.Nutrients · 2021Trial
- Relations of Insulin Resistance, Body Weight, Vitamin D Deficiency, SHBG and Androgen Levels in PCOS Patients.Biomedicines · 2025Article
- The Relationship Between the Average Decreased Times of Estradiol and Early Miscarriage: An Observational Study.Reproductive sciences (Thousand Oaks, Calif.) · 2025Observational
- Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential.Frontiers in nutrition · 2025Review
- Effect of Vitamin DCells · 2023Article
- An investigation of the potential effects of amitriptyline on polycystic ovary syndrome induced by estradiol valerate.Histochemistry and cell biology · 2023Article
- Vitamin D and calcium, together and separately, play roles in female reproductive performance.Scientific reports · 2022Article
- Effects of supraphysiological vitamin DHistochemistry and cell biology · 2021Article
- Vitamin D in follicular development and oocyte maturation.Reproduction (Cambridge, England) · 2021Review
- Assessing the effect of MitoQHeliyon · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePolycystic ovary syndrome (PCOS) as a reproductive disorder disturbs ovarian follicular development, vitamin D stimulated insulin activity, and sex hormone concentrations. This study aimed to examine the effects of vitamin D on ovarian follicular development, insulin resistance, and sex hormone changes in rats with induced PCOS. MATERIALS AND
methodsForty female Wistar rats were randomly divided into four groups: (1) control, (2) induced PCOS, (3) vitamin D-treated non-PCOS (sham group), (4) vitamin D treated PCOS groups. All rats were then sacrificed under anesthesia and ovarian tissue samples were evaluated histomorphometrically. Blood samples were collected for analyzing the serum concentrations of sex hormones and insulin resistance.
resultsThe number of atretic follicles at different stages of development increased in the PCOS ovaries (p<0.001). Vitamin D treatment significantly increased the normality of follicles in rats with PCOS (p<0.001). The serum concentration of follicle stimulating hormone and the estradiol significantly increased in rats with PCOS, whereas the testosterone and luteinizing hormone concentrations, glucose, insulin, and insulin resistance concentrations significantly decreased during vitamin D treatment (p<0.001).
conclusionThis study indicated that vitamin D treatment may protect ovarian tissue from the negative effect of PCOS by improving insulin activity and gonadotropin concentrations.
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