ArticleBMJ open respiratory research2019
Prevalence and outcome of central airway obstruction in patients with lung cancer.
Article in BMJ open respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Efficacy and safety of transbronchial microwave ablation therapy under moderate sedation in malignant central airway obstruction patients with respiratory failure: a single-institution retrospective study.Journal of cancer research and clinical oncology · 2021Trial
- Applying the CHEST Guidelines for Management of Central Airway Obstruction.CHEST pulmonary · 2026Article
- Microdebrider - Assisted management of central airway obstruction via rigid bronchoscopy: A preliminary study on safety and efficacy.Lung India : official organ of Indian Chest Society · 2026Article
- Veno-venous extracorporeal membrane oxygenation-supported rigid bronchoscopy for airway obstruction in a post-pneumonectomy patient with recurrent neuroendocrine lung cancer: a case report.Journal of visualized surgery · 2026Article
- Article
- Outcomes and Prognostic Analysis of Therapeutic Bronchoscopy in Non-Small Cell Lung Cancer (NSCLC) Patients With Respiratory Failure Secondary to Malignant Central Airway Obstruction (MCAO).Pulmonary medicine · 2026Article
- Narrative review of malignant central airway obstruction: management updates.Journal of thoracic disease · 2025Review
- A retrospective comparison of silicone and hybrid metal tracheobronchial Y stents.Journal of thoracic disease · 2025Article
- Role of interventional pulmonology in intensive care units: A scoping review.World journal of critical care medicine · 2025Review
- Long-Term Outcomes of Interventional Bronchoscopy for Central Airway Obstruction in a Single-Center Retrospective Study: A Subgroup Analysis of Malignant and Benign Lesions.Journal of clinical medicine · 2025Article
- Anesthesia for bronchoscopy interventional therapy in a patient with Gorham-Stout disease, lung cancer, and right lung atelectasis: a case report.BMC anesthesiology · 2025Article
- Article
- Palliative endoscopic treatment of malignant central airway obstruction.BMC pulmonary medicine · 2024Article
- The Clinical Utility of Pulmonary Function Tests in the Diagnosis and Characterization of Central Airway Obstruction: A Narrative Review.Journal of clinical medicine · 2024Review
- Cytomegalovirus tracheobronchitis mimicking lung cancer progression in a patient with lung adenocarcinoma: A case report.Thoracic cancer · 2024Article
- Interventional bronchoscopy in lung cancer treatment.Breathe (Sheffield, England) · 2024Review
- Correlation of Bronchoscopy and CT in Characterizing Malignant Central Airway Obstruction.Cancers · 2024Article
- Effective Differences between 2D and 3D Planned Brachytherapy in Lung Cancer: An Institutional Retrospective Study.Medicina (Kaunas, Lithuania) · 2024Article
- Challenges in diagnosis and management of central airway obstruction: Case series.SAGE open medical case reports · 2024Article
- Wirelessly Actuated Ciliary Airway Stent for Excessive Mucus Transportation.Advanced materials technologies · 2023Article
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Authors and funding
11 authors.
Funding
Abstract
Introduction: Central airway obstruction (CAO) is a life-threatening complication of lung cancer. The prevalence of CAO in lung cancer patients is unknown. We audited CAO burden to inform our local cancer service. Methods: This is a cohort review of all new lung cancer diagnoses between 1 November 2014 and 30 November 2015. CAO was defined by CT appearance. CT scans and routine patient records were followed up to 30 November 2018 to determine the prevalence of CAO at diagnosis; the characteristics of patients with prevalent CAO; mortality (using survival analysis); and incident CAO over follow-up. Results: Of 342 new lung cancer diagnoses, CAO prevalence was 13% (95% CI 10% to 17%; n=45/342). Dedicated CT scan review identified missed CAO in 14/45 (31%) cases. In patients with prevalent CAO, 27/44 (61%) had a performance status of ≤2, 23/45 (51%) were diagnosed during an acute admission and 36/44 (82%) reported symptoms. Treatments were offered to 32/45 (71%); therapeutic bronchoscopy was performed in only 8/31 (26%) eligible patients. Median survival of patients with prevalent CAO was 94 (IQR 33-274) days. Multivariate analysis, adjusting for age, gender and disease stage, found CAO on index CT scan was independently associated with an increased hazard of death (adjusted HR 1.78 (95% CI 1.27 to 2.48); p=0.001). In total, 15/297 (5%) developed CAO during follow-up (median onset 340 (IQR 114-551) days). Over the audit period, 60/342 (18%; 95% CI 14% to 22%) had or developed CAO. Discussions: This is the first description of CAO prevalence in 40 years. Patients with prevalent CAO had a higher mortality. Our data provide a benchmark for service planning.
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