ArticleJournal of global health2019
Drivers of the reduction in childhood diarrhea mortality 1980-2015 and interventions to eliminate preventable diarrhea deaths by 2030.
Article in Journal of global health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 5 of them syntheses that pooled it.
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Who cites it
72 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Estimated global and regional causes of deaths from diarrhoea in children younger than 5 years during 2000-21: a systematic review and Bayesian multinomial analysis.The Lancet. Global health · 2024Pooled it
- Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children.The Cochrane database of systematic reviews · 2023Pooled it
- Case fatality risk of diarrhoeal pathogens: a systematic review and meta-analysis.International journal of epidemiology · 2022Pooled it
- Updating the assumptions on the impact of household water, sanitation and hygiene interventions on diarrhea morbidity in young children.Journal of global health · 2022Pooled it
- 15-year experience with rotavirus vaccination in Mexico: a systematic literature review.Human vaccines & immunotherapeutics · 2021Pooled it
- Effect of 3 Days of Oral Azithromycin on Young Children With Acute Diarrhea in Low-Resource Settings: A Randomized Clinical Trial.JAMA network open · 2021Trial
- Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial.The New England journal of medicine · 2020Trial
- Gut-protective metabolic phenotype for diarrhoeal remission caused by an environmental probiotic thermophile.Microbiome · 2026Article
- Molecular typing of rotaviruses in gastroenteritis cases detected in foreign-born children aged 0-5 years.Microbiology spectrum · 2026Article
- Unraveling Streptococcus Thermophilus NCU074001-Based Anti-Diarrheal Actions Via Integrated Immune-Gut Microbiota and Tryptophan Metabolic Pathway Identification.Probiotics and antimicrobial proteins · 2026Article
- Updated Estimates of the Global, Regional and National Burden, and Etiology of Diarrheal Diseases Transmissible via Food: A Systematic Review and Meta-Analytical Modelling Study for the World Health Organization.medRxiv : the preprint server for health sciences · 2026Article
- Epidemiology of Rotavirus and Its Association with Other Etiological Agents of Enteric Infections in the Mexican Child Population (0-5 Years).Microorganisms · 2026Article
- Prevalence of acute watery diarrhea in vulnerable children, mothers' knowledge, and management: a cross-sectional study from Yemen.Frontiers in pediatrics · 2026Article
- Timely treatment-seeking for diarrheal diseases among caregivers with under-five children in public hospitals of Sidama region, Ethiopia: Unmatched case-control study.Journal of public health research · 2026Article
- Effect of a structured teaching programme on mothers' knowledge and utilisation of oral rehydration solution.African journal of primary health care & family medicine · 2025Article
- Empowering Women, Enhancing Health: The Role of Education in Water, Sanitation, and Hygiene (WaSH) and Child Health Outcomes.International journal of environmental research and public health · 2025Article
- Spatiotemporal variation of under-5 children diarrhea incidence and associated meteorological factors in central Gondar zone, Northwest Ethiopia. A retrospective time series study.BMC infectious diseases · 2025Article
- Reservations about the eClinicalMedicine report of a novel glucose-free amino acid oral rehydration solution.EClinicalMedicine · 2025Article
- Global burden of diarrhea disease in the older adult and its attributable risk factors from 1990 to 2021: a comprehensive analysis from the global burden of disease study 2021.Frontiers in public health · 2025Article
- Use of minimally invasive tissue sampling to determine the contribution of diarrheal diseases to under-five mortality and associated co-morbidities and co-infections in children with fatal diarrheal diseases in Africa and Bangladesh.PLOS global public health · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
backgroundChildhood diarrhea deaths have declined more than 80% from 1980 to 2015, in spite of an increase in the number of children in low- and middle-income countries (LMIC). Possible drivers of this remarkable accomplishment can guide the further reduction of the half million annual child deaths from diarrhea that still occur.
methodsWe used the Lives Saved Tool, which models effects on mortality due to changes in coverage of preventive or therapeutic interventions or risk factors, for 50 LMIC to determine the proximal drivers of the diarrhea mortality reduction.
resultsDiarrhea treatment (oral rehydration solution [ORS], zinc, antibiotics for dysentery and management of persistent diarrhea) and use of rotavirus vaccine accounted for 49.7% of the diarrhea mortality reduction from 1980 to 2015. Improvements in nutrition (stunting, wasting, breastfeeding practices, vitamin A) accounted for 38.8% and improvements in water, sanitation and handwashing for 11.5%. The contribution of ORS was greater from 1980 to 2000 (58.0% of the reduction) than from 2000 to 2015 (30.7%); coverage of ORS increased from zero in 1980 to 29.5% in 2000 and more slowly to 44.1% by 2015. To eliminate the remaining childhood diarrhea deaths globally, all these interventions will be needed. Scaling up diarrhea treatment and rotavirus vaccine, to 90% coverage could reduce global child diarrhea mortality by 74.1% from 2015 levels by 2030. Adding improved nutrition could increase that to 89.1%. Finally, adding increased use of improved water sources, sanitation and handwashing could result in a 92.8% reduction from the 2015 level.
conclusionsEmploying the interventions that have resulted in such a large reduction in diarrhea mortality in the last 35 years can virtually eliminate remaining childhood diarrhea deaths by 2030.
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