ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020
Alterations in functional brain networks in depressed patients with a suicide attempt history.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Clinical Utility of Functional Near-Infrared Spectroscopy for Assessment and Prediction of Suicidality: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- DNA methylation-derived age acceleration reveals neurodevelopmental and stress-linked pathways in depression and suicide.Journal of affective disorders · 2026Article
- Disentangling individual heterogeneity reveals robust network and molecular signatures of major depressive disorder with suicidal ideation.Translational psychiatry · 2026Article
- Suicide attempt history, childhood trauma, and functional brain network alterations in major depressive disorder: a resting-state functional connectivity-based multivariate pattern analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Differentiating suicide risk in treatment-resistant depression: clinical and functional imaging correlates of suicidal ideation and attempt.NeuroImage. Clinical · 2026Article
- Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review.Frontiers in integrative neuroscience · 2026Review
- Temporal dynamic changes in functional connectivity of reward network in depressed adolescents and young adults with and without suicidal attempts.BMC psychiatry · 2025Article
- Modulation of suicide-related neural circuits by transcranial magnetic stimulation and its role in reducing suicide risk.Translational psychiatry · 2025Article
- Longitudinal assessment of brain volume and shape alterations in depressive patients with differential suicidality.Discover mental health · 2025Article
- Random Walk-Based Node Feature Learning for Major Depressive Disorder Identification Through Multi-Site rs-fMRI Data.Human brain mapping · 2025Article
- Alterations in static and dynamic functional network connectivity in subcortical vascular cognitive impairment.Scientific reports · 2025Article
- Altered static and dynamic functional network connectivity in individuals with subthreshold depression: a large-scale resting-state fMRI study.European archives of psychiatry and clinical neuroscience · 2025Article
- Dynamic functional adaptations during touch observation in autism: connectivity strength is linked to attitudes towards social touch and social responsiveness.Molecular autism · 2025Article
- Disrupted small-world white matter networks in patients with major depression and recent suicide plans or attempts.Brain imaging and behavior · 2024Article
- The neural connectome of suicidality in adults with mood and anxiety disorders.Nature. Mental health · 2024Article
- Altered Effective Connectivity Among the Cerebellum and Cerebrum in Patients with Major Depressive Disorder Using Multisite Resting-State fMRI.Cerebellum (London, England) · 2023Article
- Alterations in regional homogeneity and functional connectivity associated with cognitive impairment in patients with hypertension: a resting-state functional magnetic resonance imaging study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Brain signatures in children who contemplate suicide: learning from the large-scale ABCD study.Psychological medicine · 2023Article
- Cortical hierarchy disorganization in major depressive disorder and its association with suicidality.Frontiers in psychiatry · 2023Article
- Spontaneous transient states of fronto-temporal and default-mode networks altered by suicide attempt in major depressive disorder.European archives of psychiatry and clinical neuroscience · 2022Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Suicide is a major challenge in public health and is strongly associated with major depressive disorder (MDD). Despite recent neuroimaging developments, the neural correlates of suicide behavior in patients with MDD remain unclear. Independent component analysis (ICA) for neuroimaging data allows the identification of functional brain networks without prior regions of interest and may help to identify neurobiological markers of specific disorders. Using ICA, we investigated the differences in resting-state brain networks in patients with MDD who had or did not have a history of suicide attempts and in healthy controls (HCs). Suicidal depressed (SD) patients, non-suicidal depressed (NSD) patients, and HCs significantly differed from each other in the pattern of connectivity of multiple functional networks, network synchronization, and functional network connectivity (FNC). The patient groups had a decreased network synchronization in the insular, cerebellum, basal ganglia, thalamus, operculum, frontoparietal cortices, and sensory cortices relative to the HCs. The decreased FNC between these networks (insular-default mode network and insular-cerebellum) was found in the SD group compared to the NSD and HC groups. These differences were not related to illness duration and medication status differences between SD and NSD. Furthermore, the degree of FNC in these networks was associated with the suicide ideation and stress level. Our results demonstrated that widespread but discrete network changes in brain networks and their interconnectivity was associated with suicide attempts in patients with MDD. Our results suggest that the neural basis underlying the psychopathology of attempted suicide in patients with MDD involves multiple brain networks and their interaction.
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