ArticleScientific reports2019
Microplastics induce transcriptional changes, immune response and behavioral alterations in adult zebrafish.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 363 citations in OpenAlex.
- Global research trends and mechanistic pathways linking micro- and nano plastics exposure to metabolic health: a bibliometric and evidence-mapping analysis (2013-2025).Frontiers in nutrition · 2026Pooled it
- Invisible invaders: unveiling the carcinogenic threat of microplastics and nanoplastics in colorectal cancer-a systematic review.Frontiers in public health · 2025Pooled it
- Review
- Investigating the Release and Toxicity of Microplastics/Nanoplastics From Single-Use Plastic Bags to Zebrafish.Journal of applied toxicology : JAT · 2026Article
- Microplastic-induced changes in the rainbow trout gut: Insights from transcriptomic, proteomic, and microbial approaches.Veterinarni medicina · 2026Article
- Review
- Toxic effects of MPs and Up GradeVeterinary research communications · 2026Article
- Transcriptomic Insights into Micro- and Nanoplastic Toxicity in Zebrafish: A Narrative Review.Toxics · 2026Review
- The Particle Size Effect: Cytotoxicity and Cellular Uptake of Polystyrene Nanoplastics in Human Keratinocytes.Toxics · 2026Article
- Oxidative aging facilitates biological barrier penetration of polyethylene microplastics, amplifying systemic lipotoxicity in aquatic species.Particle and fibre toxicology · 2026Article
- Biological alterations of polyvinyl chloride (PVC) microplastics on Danio rerio at environmentally relevant concentrations - risk assessment.Fish physiology and biochemistry · 2026Article
- Transcriptome and Gene Family Analyses Reveal the Physiological and Immune Regulatory Mechanisms ofAntioxidants (Basel, Switzerland) · 2026Article
- Microplastics Induced Dysfunctions in Physiology and Behavior of Fish: A Comprehensive Review.Journal of toxicology · 2026Review
- Review
- Polystyrene and polyethylene terephthalate nanoplastics differentially impact mouse ovarian follicle function.Environmental pollution (Barking, Essex : 1987) · 2025Article
- PET microplastics alter the transcriptome profile and oxidative stress markers in the liver of immature piglets: an in vivo study.Archives of toxicology · 2025Article
- Cellular and Molecular Mechanisms of Micro- and Nanoplastics Driving Adverse Human Health Effects.Toxics · 2025Review
- The rise of historical epigenomics and temporal analysis of gene regulation.Genome biology · 2025Review
- CD44 as a Central Integrator of Inflammation and Fibrosis: From Molecular Signaling to Environmental Modulation.International journal of molecular sciences · 2025Review
- Polystyrene and polyethylene terephthalate nanoplastics differentially impact mouse ovarian follicle function.bioRxiv : the preprint server for biology · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microplastics have become pervasive environmental pollutants in both freshwater and marine ecosystems. The presence of microplastics have been recorded in the tissues of many wild fish species, and laboratory studies have demonstrated that microplastics can exert adverse health effects. To further investigate the biological mechanisms underlying microplastics toxicity we applied an integrated approach, analyzing the effects of microplastics at transcriptomic, histological and behavioral level. Adult zebrafish have been exposed to two concentrations of high-density polyethylene and polystyrene microplastics for twenty days. Transcriptomic results indicate alterations in the expression of immune system genes and the down-regulation of genes correlated with epithelium integrity and lipid metabolism. The transcriptomic findings are supported by tissue alterations and higher occurrence of neutrophils observed in gills and intestinal epithelium. Even the daily rhythm of activity of zebrafish appears to be affected, although the regular pattern of activity is recovered over time. Considering the transcriptomic and histological findings reported, we hypothesize that the effects on mucosal epithelium integrity and immune response could potentially reduce the organism defense against pathogens, and lead to a different utilization of energy stores.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.