ArticleScientific reports2019
Correlation of axial length and myopic macular degeneration to levels of molecular factors in the aqueous.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Aqueous humour concentrations of HB-EGF, EGF and VEGF-A and axial length in humans.Acta ophthalmologica · 2025Article
- [Assessment of myopia progression].Die Ophthalmologie · 2025Review
- Causal relationships between inflammatory cytokines and myopia: an analysis of genetic and observational studies.Annals of medicine and surgery (2012) · 2024Article
- Innate immune responsive inflammation in development of progressive myopia.Eye (London, England) · 2024Article
- Molecular changes in intraocular fluid: implications for myopia.International journal of biological sciences · 2024Review
- Structural, blood flow and functional changes in the macular area and the expression of aqueous humor factors in myopia.Frontiers in medicine · 2024Article
- Expression of cytokines in the aqueous humor of cataract patients with pathologic myopia and simple high myopia.Molecular vision · 2024Article
- Biomarker Signature in Aqueous Humor Mirrors Lens Epithelial Cell Activation: New Biomolecular Aspects from Cataractogenic Myopia.Biomolecules · 2023Article
- Myopia Is Suppressed by Digested Lactoferrin or Holo-Lactoferrin Administration.International journal of molecular sciences · 2023Article
- Correlation of vitreous chamber depth with ocular biometry in high axial myopia.Indian journal of ophthalmology · 2022Article
- IMI Pathologic Myopia.Investigative ophthalmology & visual science · 2021Review
- Association between MMP-2 gene polymorphism and cataract susceptibility: A protocol for systematic review and meta-analysis.Medicine · 2021Article
- Complications of high myopia: An update from clinical manifestations to underlying mechanisms.Advances in ophthalmology practice and researchReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To elucidate the molecular processes associated with the development of myopic macular degeneration (MMD), we measured the intraocular concentrations of molecular factors in emmetropic and myopic eyes. This is a retrospective clinic-based case-control study that included eyes undergoing routine cataract surgery whereby aqueous humour samples were obtained. We measured the concentrations of pigment epithelium derived factor(PEDF), matrix metalloproteinase 2(MMP-2), tissue inhibitor of metalloproteinase(TIMP-2), vascular endothelial growth factor isoform A(VEGF-A), interleukin 8(IL-8), interleukin 6(IL-6), C-reactive protein(CRP), angiopoietin 2(Ang2), and amphiregulin. 38 eyes (axial length (AL): 22.4-32.4 mm), including 12 highly myopic (HM) eyes (AL ≥ 26.5 mm) without MMD and 12 HM eyes with MMD but without neovascularization were included. Eyes with MMD were found to have significantly lower VEGF-A levels (p = 0.007) and higher MMP-2 levels (p = 0.02) than control eyes after adjusting for age and gender. MMP-2 levels correlated positively (r = 0.58, p = 0.002), while VEGF-A levels correlated negatively with longer axial length (r = -0.75, p < 0.001). Both the concentrations of VEGF-A (P = 0.25) and MMP-2 (P = 0.69) were not significantly associated with MMD after adjusting for AL. These findings suggest that the predominant mechanism underlying the development of non-neovascular MMD may be axial elongation, driven in part by MMP-2 related mechanisms.
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