ArticleNature communications2019
Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 140 papers, 8 of them syntheses that pooled it.
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140citing papers in PubMed, 8 pooled it
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Who cites it
140 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Specificity in the commonalities of inhibition control: using meta-analysis and regression analysis to identify the key brain regions in psychiatric disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2024Pooled it
- Systematic review and meta-analysis: multimodal functional and anatomical neural alterations in autism spectrum disorder.Molecular autism · 2024Pooled it
- A Meta-Analysis of Autism and Clinical High-Risk for Psychosis is Too Premature. Comment on: Vaquerizo-Serrano, Salazar de Pablo, Singh & Santosh (2021).Journal of autism and developmental disorders · 2022Pooled it
- Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- Emerging behavioral and neuroimaging biomarkers for early and accurate characterization of autism spectrum disorders: a systematic review.Translational psychiatry · 2021Pooled it
- Sex/gender differences in the human autistic brains: A systematic review of 20 years of neuroimaging research.NeuroImage. Clinical · 2021Pooled it
- Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings.NeuroImage. Clinical · 2021Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Widespread alterations in white matter microstructure in autism: A multilevel meta-analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Functional Brain Asymmetry Reveals Heterogeneous Subtypes in Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Article
- Autism spectrum disorder across the lifespan: Dynamic symptom trajectories and multidimensional support framework.Molecular psychiatry · 2026Review
- Autism and Cortical Thickness Deviation From Neurotypical Controls: Evidence for a Spatial Association With Serotonin Receptors.Autism research : official journal of the International Society for Autism Research · 2026Article
- Individualized cortical thickness asymmetry in autism spectrum disorder and schizophrenia.Molecular psychiatry · 2026Article
- Structural and functional brain asymmetry in relation to heterogeneous causes of situs inversus totalis.Brain structure & function · 2026Article
- Functional connectivity in infants' visual cortex and its links to motion processing and autism.Scientific reports · 2026Article
- Unraveling the Autism Spectrum Heterogeneity: Insights From ABIDE I Database Using Data/Model-Driven Permutation Testing Approaches.Brain and behavior · 2026Article
- Tractometry-Based Quantification of Along-Tract White-Matter Hemispheric Asymmetry in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2026Article
- Non-right-handedness and psychiatric disorders: A synthesis of epidemiological, genetic, and neurobiological evidence.World journal of psychiatry · 2026Review
- Cortical Thickness and Curvature in Autism and ADHD: A Mega-Analysis.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal Structural Asymmetry Mediates Body Mass Index and Treatment Response in Major Depressive Disorder.Depression and anxiety · 2026Article
80 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
58 authors.
Merel C PostemaDepartment of Language & Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0002-1536-7062
Daan van RooijDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands.
Evdokia AnagnostouBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Department of Pediatrics, University of Toronto, Toronto, USA.
Celso ArangoChild and Adolescent Psychiatry Department, Gregorio Marañón General University Hospital, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.
Guillaume AuziasInstitut de Neurosciences de la Timone, UMR 7289, Aix Marseille Université, CNRS, Marseille, France.ORCID http://orcid.org/0000-0002-0414-5691
Marlene BehrmannDepartment of Psychology, Carnegie Mellon University, Pittsburgh, PA, USA.
Geraldo Busatto FilhoLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Sara CalderoniIRCCS Stella Maris Foundation, viale del Tirreno 331, 56128, Pisa, Italy.
Rosa CalvoDepartment of Child and Adolescent Psychiatry and Psychology Hospital Clinic, Psychiatry Unit, Department of Medicine, 2017SGR881, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Eileen DalyDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience King's College London, London, UK.
Christine DeruelleInstitut de Neurosciences de la Timone, UMR 7289, Aix Marseille Université, CNRS, Marseille, France.
Adriana Di MartinoInstitute for Pediatric Neuroscience, NYU Child Study Center, New York, NY, USA.
Ilan DinsteinDepartment of Psychology, Ben-Gurion University of the Negev, Beer Sheva, Israel.ORCID http://orcid.org/0000-0001-8106-5209
Fabio Luis S DuranLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-7603-6152
Sarah DurstonBrain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
Christine EckerDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.
Stefan EhrlichDepartment of Child and Adolescent Psychiatry, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany.
Damien FairDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0001-8602-393X
Jennifer FedorDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Xin FengBioKnow Health Informatics Lab, College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Jilin, 130012, China.
Jackie FitzgeraldDepartment of Psychiatry, School of Medicine, Trinity College, Dublin, Ireland.
Dorothea L FlorisDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands.
Christine M FreitagDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.ORCID http://orcid.org/0000-0001-9676-4782
Louise GallagherDepartment of Psychiatry, School of Medicine, Trinity College, Dublin, Ireland.
David C GlahnDepartment of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115-5724, USA.
Ilaria GoriNational Institute for Nuclear Physics, Pisa Division, Largo B. Pontecorvo 3, 56124, Pisa, Italy.
Shlomi HaarDepartment of Bioengineering, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-2213-6585
Liesbeth HoekstraDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA.ORCID http://orcid.org/0000-0003-4401-8950
Maria JalbrzikowskiDepartment of Psychiatry, School of Medicine, Trinity College, Dublin, Ireland.
Joost JanssenChild and Adolescent Psychiatry Department, Gregorio Marañón General University Hospital, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.
Joseph A KingDepartment of Child and Adolescent Psychiatry, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0002-2864-5578
Xiang Zhen KongDepartment of Language & Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.
Luisa LazaroDepartment of Child and Adolescent Psychiatry and Psychology Hospital Clinic, Psychiatry Unit, Department of Medicine, 2017SGR881, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Jason P LerchNeurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
Beatriz LunaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Mauricio M MartinhoDepartment of Neuropsychiatry, Universidade Federal de Santa Maria, Santa Maria, Brazil.
Jane McGrathDepartment of Psychiatry, School of Medicine, Trinity College, Dublin, Ireland.
Sarah E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Filippo MuratoriIRCCS Stella Maris Foundation, viale del Tirreno 331, 56128, Pisa, Italy.
Clodagh M MurphyDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience King's College London, London, UK.ORCID http://orcid.org/0000-0002-6350-0155
Declan G M MurphyBehavioural Genetics Clinic, Adult Autism Service, Behavioural and Developmental Psychiatry Clinical Academic Group, South London and Maudsley Foundation NHS Trust, London, UK.ORCID http://orcid.org/0000-0002-6664-7451
Kirsten O'HearnDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Bob OranjeBrain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
Mara ParelladaChild and Adolescent Psychiatry Department, Gregorio Marañón General University Hospital, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.
Olga PuigDepartment of Child and Adolescent Psychiatry and Psychology Hospital Clinic, Psychiatry Unit, Department of Medicine, 2017SGR881, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.ORCID http://orcid.org/0000-0002-0533-5542
Alessandra ReticoNational Institute for Nuclear Physics, Pisa Division, Largo B. Pontecorvo 3, 56124, Pisa, Italy.ORCID http://orcid.org/0000-0001-5135-4472
Pedro RosaLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Katya RubiaInstitute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.
Devon ShookBrain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
Margot J TaylorDiagnostic Imaging Research, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Michela TosettiIRCCS Stella Maris Foundation, viale del Tirreno 331, 56128, Pisa, Italy.ORCID http://orcid.org/0000-0002-2515-7560
Gregory L WallaceDepartment of Speech, Language, and Hearing Sciences, The George Washington University, Washington, DC, USA.
Fengfeng ZhouBioKnow Health Informatics Lab, College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Jilin, 130012, China.ORCID http://orcid.org/0000-0002-8108-6007
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA.
Simon E FisherDepartment of Language & Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0002-3132-1996
Jan K BuitelaarDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-8288-7757
Clyde FrancksDepartment of Language & Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands. clyde.francks@mpi.nl.
Funding
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MMedical Research Council MR/N026063/1NIBIB NIH HHS U54 EB020403
Abstract
Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface area. These differences generally involved reduced asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen's d = -0.13, for asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of brain structural asymmetry in ASD.
Indexed as
AdolescentAdultAutism Spectrum DisorderBrainCase-Control StudiesCerebral CortexChildFemaleFrontal LobeGyrus CinguliHumansMagnetic Resonance ImagingMaleMiddle AgedOrgan SizePrefrontal Cortex
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