ArticleScientific reports2019
A Clearing Technique to Enhance Endogenous Fluorophores in Skin and Soft Tissue.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Spatiotemporal decoding of skin biology: development, aging, disease, and regeneration.Burns & trauma · 2026Article
- Rapid sonication-assisted whole tissue clearing and immunostaining.Scientific reports · 2025Article
- Optomechanical Properties of Swine Skin Tissue Treated With a Nontoxic Optical Clearing Agent.Journal of biophotonics · 2025Article
- Progress on three-dimensional visualizing skin architecture with multiple immunofluorescence staining and tissue-clearing approaches.Histology and histopathology · 2025Review
- Improving Complex Coacervate Tissue Adhesive Performance Using Bridging Polymer Chains.Biomacromolecules · 2025Article
- Article
- Deep imaging of LepRBone research · 2025Article
- Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin.Cancer cell · 2022Article
- Integrated spatial multiomics reveals fibroblast fate during tissue repair.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review
- High-resolution 3D fluorescent imaging of intact tissues.International journal of cardiology and cardiovascular diseases · 2021Article
- Monitoring calcium-induced epidermal differentiation in vitro using multiphoton microscopy.Journal of biomedical optics · 2020Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Fluorescent proteins are used extensively in transgenic animal models to label and study specific cell and tissue types. Expression of these proteins can be imaged and analyzed using fluorescent and confocal microscopy. Conventional confocal microscopes cannot penetrate through tissue more than 4-6 μm thick. Tissue clearing procedures overcome this challenge by rendering thick specimens into translucent tissue. However, most tissue clearing techniques do not satisfactorily preserve expression of endogenous fluorophores. Using simple adjustments to the BABB (Benzoic Acid Benzyl Benzoate) clearing methodology, preservation of fluorophore expression can be maintained. Modified BABB tissue clearing is a reliable technique to clear skin and soft tissue specimens for the study of dermal biology, wound healing and fibrotic pathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.