ArticleNature communications2019
Procr-expressing progenitor cells are responsible for murine ovulatory rupture repair of ovarian surface epithelium.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Characterization of ovarian progenitor cells for their potential to generate steroidogenic theca cells in vitro.Reproduction (Cambridge, England) · 2024Article
- Calcified apoptotic vesicles from PROCRJournal of extracellular vesicles · 2024Article
- Identification and characterization of multipotential stem cells in immortalized normal ovarian surface epithelial cells.Acta biochimica et biophysica Sinica · 2024Article
- Islet organoids: a new hope for islet transplantation in diabetes.Frontiers in immunology · 2024Review
- Chronic stress induces meiotic arrest failure and ovarian reserve decline via the cAMP signaling pathway.Frontiers in endocrinology · 2023Article
- Identification of curcumin as a novel potential drug for promoting the development of small ovarian follicles for infertility treatment.PNAS nexus · 2022Article
- Article
- Recent advances in tissue stem cells.Science China. Life sciences · 2021Review
- Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs.Bone research · 2021Article
- Lentiviral CRISPR-guided RNA library screening identified Adam17 as an upstream negative regulator of Procr in mammary epithelium.BMC biotechnology · 2021Article
- Expression of NR5A2, NUP153, HNF4A, USP15 and FNDC3B is consistent with their use as novel biomarkers for bovine mammary stem/progenitor cells.Journal of molecular histology · 2021Article
- Procr-expressing granulosa cells are highly proliferative and are important for follicle development.iScience · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ovarian surface epithelium (OSE) undergoes recurring ovulatory rupture and repair. The OSE replenishing mechanism post ovulation remains unclear. Here we report that the expression of Protein C Receptor (Procr) marks a progenitor population in adult mice that is responsible for OSE repair post ovulation. Procr+ cells are the major cell source for OSE repair. The mechanism facilitating the rapid re-epithelialization is through the immediate expansion of Procr+ cells upon OSE rupture. Targeted ablation of Procr+ cells impedes the repairing process. Moreover, Procr+ cells displayed robust colony-formation capacity in culture, which we harnessed and established a long-term culture and expansion system of OSE cells. Finally, we show that Procr+ cells and previously reported Lgr5+ cells have distinct lineage tracing behavior in OSE homeostasis. Our study suggests that Procr marks progenitor cells that are critical for OSE ovulatory rupture and homeostasis, providing insight into how adult stem cells respond upon injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.