Evidence map›Paper›PMID 31672969›Full record

ArticleNature communications2019

Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca

George Khelashvili, Maria E Falzone, Xiaolu Cheng, Byoung-Cheol Lee, Alessio Accardi, Harel Weinstein

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. TMEM16 proteins: CaInternational journal of molecular medicine · 2024
    Review
  7. Structural basis of closed groove scrambling by a TMEM16 protein.Nature structural & molecular biology · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Polymodal Control of TMEM16x Channels and Scramblases.International journal of molecular sciences · 2022
    Review
  18. Article
  19. Article
  20. An outer-pore gate modulates the pharmacology of the TMEM16A channel.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

George KhelashviliDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY, 10065, USA. gek2009@med.cornell.edu.ORCID http://orcid.org/0000-0001-7235-8579
Maria E FalzoneDepartment of Biochemistry, Weill Cornell Medical College of Cornell University, New York, NY, 10065, USA.
Xiaolu ChengDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0002-2785-6488
Byoung-Cheol LeeResearch Group for the Neurovascular Unit, Korea Brain Research Institute, Daegu, Republic of Korea.
Alessio AccardiDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY, 10065, USA. ala2022@med.cornell.edu.ORCID http://orcid.org/0000-0002-6584-0102
Harel WeinsteinDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY, 10065, USA. haw2002@med.cornell.edu.ORCID http://orcid.org/0000-0003-3473-9818
Cornell University · US

Funding

TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7M
Ca2+-dependent lipid scrambling and ion transport by TMEM16 proteinsR01GM106717 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ACCARDI, ALESSIO, WEINSTEIN, HAREL · 2014 to 2023
$4.3M
Breakthrough Molecular Dynamics Research via an Anton2 SupercomputerR01GM116961 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D. · 2016 to 2023
$3.0M
NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R01 GM106717NIGMS NIH HHS R01 GM116961U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM106717
6 · The paper itself

Abstract

Both lipid and ion translocation by Ca

Indexed as

AnoctaminsBiological TransportCalciumChloridesCryoelectron MicroscopyFungal ProteinsHydrophobic and Hydrophilic InteractionsIon TransportMolecular Docking SimulationNectriaPhospholipidsProtein ConformationAnoctaminsCalciumChloridesFungal ProteinsPhospholipids

Identifiers

PMID31672969
PMCPMC6823365
OpenAlexW2982382682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.