ArticleMedical science monitor : international medical journal of experimental and clinical research2019
Marital Status and Survival in Osteosarcoma Patients: An Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Marital status and survival in cancer patients: A systematic review and meta-analysis.Cancer medicine · 2023Pooled it
- Development of a prognostic nomogram for metastatic pancreatic ductal adenocarcinoma integrating marital status.Scientific reports · 2022Trial
- Survival nomogram for patients with bone metastatic renal cell carcinoma: A population-based study.International braz j urol : official journal of the Brazilian Society of UrologyTrial
- Article
- Time to treatment initiation and overall survival in osteosarcoma: a national cancer database analysis.Bone & joint open · 2026Article
- Clinical Significance of Marital Status and Changes in Status Extracted from Unstructured Clinical Notes Using Ensembles of Off-the-Shelf Extraction Models.Research square · 2025Article
- Development and validation of a nomogram integrating marital status for 5-year overall survival of chondrosarcoma: a population-based study.Discover oncology · 2024Article
- Clinical Features, Risk Factors, and Prediction Nomogram for Primary Spinal Osteosarcoma: A Large-Cohort Retrospective Study.Global spine journal · 2024Article
- Establishment and validation of systematic prognostic nomograms in patients over 60 years of age with osteosarcoma: A multicenter external verification study.Cancer medicine · 2023Article
- LncRNA KIAA0087 suppresses the progression of osteosarcoma by mediating the SOCS1/JAK2/STAT3 signaling pathway.Experimental & molecular medicine · 2023Article
- NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression.Cancer research · 2022Article
- Chemotherapy-induced amenorrhea and its effects on fertility in long-term female survivors of classic osteosarcoma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Downregulation of miR-588 is associated with tumor progression and unfavorable prognosis in patients with osteosarcoma.Experimental and therapeutic medicine · 2021Article
- Analysis and Construction of a Competitive Endogenous RNA Regulatory Network of Baicalin-Induced Apoptosis in Human Osteosarcoma Cells.BioMed research international · 2021Article
- Application of tumor-targeting peptide-decorated polypeptide nanoparticles with doxorubicin to treat osteosarcoma.Drug delivery · 2020Article
- microRNA-216b enhances cisplatin-induced apoptosis in osteosarcoma MG63 and SaOS-2 cells by binding to JMJD2C and regulating the HIF1α/HES1 signaling axis.Journal of experimental & clinical cancer research : CR · 2020Article
- Marital status impacts survival in patients with upper tract urothelial carcinoma: a population-based, propensity-matched study.Translational andrology and urology · 2020Article
- Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study.Journal of orthopaedic surgery and research · 2020Article
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3 authors.
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Abstract
BACKGROUND As the most malignant bone tumor globally, osteosarcoma has drawn increased attention. However, no studies have focused on the association between marital status and survival rate. The objectives of this study were to determine the association between marital and survival rate of osteosarcoma patients based on the SEER database. MATERIAL AND METHODS We enrolled a total of 2725 osteosarcoma patients between 1973 and 2015, including 1184 married, 154 divorced/separated, 136 widowed, and 1251 never-married patients. Survival rate was determined based on the Kaplan-Meier method in different marital subgroups. Multivariate Cox regression analysis was performed to explore independent prognostic factors. RESULTS The 5-year overall survival (OS) and cancer-specific survival (CSS) rates of the married, separated/divorced, widowed, and never-married subjects were 45.93%, 41.39%, 19.08%, and 57.21% (OS), and 49.97%, 45.85%, 22.14%, and 60.69% (CSS), respectively. The survival outcome among subgroups exhibited a clear difference, with a log-rank test p-value <0.0001. Multivariate Cox regression showed that widowhood served as the independent prognostic factor for decreased OS rather than marriage (HR, 1.246; 95% CI, 1.011-1.536; p-value=0.039) and CSS (HR, 1.34; 95% CI, 1.07-1.68; p-value=0.01). Moreover, the OS and CSS in widowed patients were lower. Additionally, based on the propensity score matching (PSM) method, the prognosis of married patients was better than that of unmarried subjects. CONCLUSIONS Marital status was correlated with the survival rate, meaning that married patients had higher survival than widowed subjects, who had worse prognoses of osteosarcoma.
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