ArticleScience (New York, N.Y.)2019
Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair.
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Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
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Who cites it
72 citing papers in PubMed, 115 citations in OpenAlex.
- Itaconate: a dual-edged sword in immunometabolism and host-pathogen interactions.Archives of microbiology · 2026Review
- Itaconate metabolism in regulated cell death.Molecular and cellular biochemistry · 2026Review
- Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026Review
- Unconventional Biocatalytic Strategies Orchestrate the Synthesis of the Nucleoside Analog Sinefungin.Journal of the American Chemical Society · 2026Article
- Offense and defense: itaconate mediates bidirectional immune regulation of host-bacteria interaction.Journal of biomedical science · 2026Review
- Targeted silencing of CLYBL with platelet-mimetic siRNA nanoparticles drives itaconate-mediated macrophage reprogramming and protects against sepsis-triggered lung cell death.Cell death discovery · 2026Article
- Human iPSC-derived alveolar macrophages reveal macrophage subtype functions of itaconate in M. tuberculosis defense.JCI insight · 2026Article
- Itaconate and its derivatives ameliorate autoimmunity by suppressing Th17 cells via regulating mitophagy.Cell communication and signaling : CCS · 2026Article
- Metabolic reprogramming of macrophages during mycobacterial infection: a review of immunometabolic crosstalk and pathogen manipulation.Frontiers in cellular and infection microbiology · 2026Review
- Cobamide metabolism, regulation, and adaptation inJournal of bacteriology · 2025Review
- Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity.Nature communications · 2025Article
- Covalent Docking to the Active Sites of Thiamine Diphosphate-Dependent Enzymes.Molecules (Basel, Switzerland) · 2025Article
- Metabolic reprogramming of immune cells in the battle against intracellular bacterial chronic infections: novel mechanisms and breakthroughs.Molecular biology reports · 2025Review
- 5-Hydroxylysine Captures the Suicidally-Inactivated Conformational State of Lysine 5,6-Aminomutase.International journal of molecular sciences · 2025Article
- In vivo itaconate tracing reveals degradation pathway and turnover kinetics.Nature metabolism · 2025Article
- Itaconic Acid: A Regulator of Immune Responses and Inflammatory Metabolism.Current issues in molecular biology · 2025Review
- Recycling for a cleaner metabolism.Nature chemical biology · 2025Article
- CLYBL averts vitamin BNature chemical biology · 2025Article
- Alveolar and Bone Marrow-derived Macrophages Differ in Metabolism and Glutamine Utilization.American journal of respiratory cell and molecular biology · 2025Article
- Itaconate and its derivatives as anti-pathogenic agents.RSC advances · 2025Review
12 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 4 institutions in 1 country.
Markus RuetzDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-9540-7310
Gregory C CampanelloDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Meredith PurchalDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Hongying ShenHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-2115-7037
Liam McDevittDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Harsha GoudaDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4511-5875
Shoko WakabayashiDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Cambridge, MA 02115, USA.
Junhao ZhuDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Cambridge, MA 02115, USA.
Eric J RubinDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Cambridge, MA 02115, USA.ORCID 0000-0001-5120-962X
Kurt WarnckeDepartment of Physics, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-3587-3720
Vamsi K MoothaHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0001-9924-642X
Markos KoutmosDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-0933-6312
Ruma BanerjeeDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. rbanerje@umich.edu.ORCID 0000-0001-8332-3275
University of Michigan · USHarvard University · USBroad Institute · USEmory University · US
Funding
The roles of genes critical for growth under defined conditions in vitro or duriU19AI107774 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI CARR, STEVEN A, FORTUNE, SARAH · 2013 to 2017
$13.2MREACTION MECHANISMS OF MAMMALIAN B12-DEPENDENT ENZYMESR01DK045776 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI RUMA V BANERJEE · 1998 to 2026
$9.7MCo(II)-Radical Pair Dynamics in B12 Enzyme CatalysisR01DK054514 · NIDDK · EMORY UNIVERSITY · PI WARNCKE, KURT · 1998 to 2019
$4.2MMitochondrial Parts, Pathways, and PathogenesisR35GM122455 · NIGMS · BROAD INSTITUTE, INC. · PI MOOTHA, VAMSI KRISHNA · 2017 to 2021
$4.0MCo(II) Radical Pair Dynamics in B12 Enzyme CatalysisR01GM142113 · NIGMS · EMORY UNIVERSITY · PI WARNCKE, KURT · 2020 to 2023
$1.3MAn integrated approach to the study of mitochondrial vitamin B12 pathway and type II fatty acid synthesisR00GM124296 · NIGMS · YALE UNIVERSITY · PI SHEN, HONGYING · 2020 to 2022
$747kAn integrated approach to the study of mitochondrial vitamin B12 pathway and type II fatty acid synthesisK99GM124296 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, HONGYING · 2017 to 2018
$180kStructural Enzymology of Mitochondrial B12 Trafficking ProteinsF32GM113405 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAMPANELLO, GREGORY · 2015 to 2016
$112kHoward Hughes Medical InstituteNHLBI NIH HHS HHSN268201300022CNIAID NIH HHS U19 AI107774NIDDK NIH HHS R01 DK045776NIDDK NIH HHS R01 DK054514NIGMS NIH HHS F32 GM113405NIGMS NIH HHS K99 GM124296NIGMS NIH HHS R00 GM124296NIGMS NIH HHS R01 GM142113NIGMS NIH HHS R35 GM122455
Abstract
Itaconate is an immunometabolite with both anti-inflammatory and bactericidal effects. Its coenzyme A (CoA) derivative, itaconyl-CoA, inhibits B
Indexed as
BiocatalysisCatalytic DomainCoenzyme ACrystallography, X-RayDeoxyadenosinesElectron Spin Resonance SpectroscopyHumansHydrogen BondingMacrophagesMethylmalonyl-CoA MutaseModels, MolecularMycobacterium tuberculosisPropionatesProtein ConformationProtein MultimerizationProtein Subunits2'-deoxyadenosineCoenzyme ADeoxyadenosinesitaconic acidMethylmalonyl-CoA MutasePropionatesProtein SubunitsSuccinatesVitamin B 12
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.