ArticleScience immunology2019
Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles.
Article in Science immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 72 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Unravelling the Measles Paradox in Children: a Disease Associated With Both Immune Suppression and Immune Activation
Unravelling the Measles Paradox: a Disease Associated With Both Immune Suppression and Immune Activation
Who cites it
72 citing papers in PubMed, 131 citations in OpenAlex.
- Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans.Science (New York, N.Y.) · 2025Trial
- Targeted pneumococcal conjugate vaccination strategies for high-risk children.Human vaccines & immunotherapeutics · 2026Review
- Extracorporeal membrane oxygenation for life-threatening measles in children: a case series.European journal of pediatrics · 2026Article
- Pediatric Measles and Visceral Leishmaniasis Co-infection: Diagnostic Challenges and Insights Into Pathophysiology.Cureus · 2026Article
- VRC01-CLASS PRECURSOR FREQUENCY IN AN AFRICAN POPULATION IS INFLUENCED BY IGHV1-2 ALLELIC COMPOSITION AND NOT MALARIA EXPOSURE.Research square · 2026Article
- Measles epidemic in Yakusu Health Zone, Democratic Republic of Congo, 2018-2019: a retrospective observational study.BMC infectious diseases · 2026Observational
- Measles challenges: global resurgence and factors affecting eradication.Italian journal of pediatrics · 2026Review
- Three paradoxical paradigms of measles virus.PLoS pathogens · 2026Article
- Measles: An Updated Literature Review of the Host Response, Pathogenesis, Complications, Prevention Measures, and Recent Outbreaks.Current issues in molecular biology · 2026Review
- Microcin C7 Prevents Cyclophosphamide-Induced Immunosuppression and Intestinal Injury by Modulating T-Cell Differentiation and Gut Microbiota Composition in Mice.Microorganisms · 2026Article
- Measles virus reprograms CD4Frontiers in cell and developmental biology · 2026Article
- Review
- Review
- Epidemiology, clinical overview, and potential risk of a new pandemic of measles virus.Infectious diseases & immunity · 2025Review
- Investigating immune amnesia after measles virus infection in two West African countries: A study protocol.PloS one · 2025Article
- On the carrying capacity of the bone marrow survival niche in mice.Frontiers in immunology · 2025Article
- The Epidemiology and Diagnosis of Measles—Special Aspects Relating to Low Incidence.Deutsches Arzteblatt international · 2024Review
- Seroprevalence of measles antibodies in women born between 1985 and 1999 in metropolitan city in India: a cross-sectional study.BMJ public health · 2024Article
- Childhood B cell leukemia: Intercepting the paths to progression.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Review
- What's going on with measles?Journal of virology · 2024Review
12 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 7 institutions in 5 countries.
Funding
Abstract
Measles is a disease caused by the highly infectious measles virus (MeV) that results in both viremia and lymphopenia. Lymphocyte counts recover shortly after the disappearance of measles-associated rash, but immunosuppression can persist for months to years after infection, resulting in increased incidence of secondary infections. Animal models and in vitro studies have proposed various immunological factors underlying this prolonged immune impairment, but the precise mechanisms operating in humans are unknown. Using B cell receptor (BCR) sequencing of human peripheral blood lymphocytes before and after MeV infection, we identified two immunological consequences from measles underlying immunosuppression: (i) incomplete reconstitution of the naïve B cell pool leading to immunological immaturity and (ii) compromised immune memory to previously encountered pathogens due to depletion of previously expanded B memory clones. Using a surrogate model of measles in ferrets, we investigated the clinical consequences of morbillivirus infection and demonstrated a depletion of vaccine-acquired immunity to influenza virus, leading to a compromised immune recall response and increased disease severity after secondary influenza virus challenge. Our results show that MeV infection causes changes in naïve and memory B lymphocyte diversity that persist after the resolution of clinical disease and thus contribute to compromised immunity to previous infections or vaccinations. This work highlights the importance of MeV vaccination not only for the control of measles but also for the maintenance of herd immunity to other pathogens, which can be compromised after MeV infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.