ArticleeNeuro
A Novel Birthdate-Labeling Method Reveals Segregated Parallel Projections of Mitral and External Tufted Cells in the Main Olfactory System.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Birth Date-Dependent Tracing of Neuronal Cell Lineage.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Differentiation timing-dependent axon targeting and subtype specification in retinal ganglion cells.Frontiers in neuroscience · 2026Article
- Developmental Olfactory Dysfunction and Abnormal Odor Memory in Immune-ChallengedThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Synaptic Connectivity and Electrophysiological Properties of the Nucleus of the Lateral Olfactory Tract.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Circuit formation and sensory perception in the mouse olfactory system.Frontiers in neural circuits · 2024Review
- Effects of prenatal alcohol exposure on the olfactory system development.Frontiers in neural circuits · 2024Review
- One respiratory cycle as a minimum time unit for making behavioral decisions in the mammalian olfactory system.Frontiers in neuroscience · 2024Article
- Olfactory information processing viewed through mitral and tufted cell-specific channels.Frontiers in neural circuits · 2024Review
- Neurogenic timing of the inferior olive subdivisions is related to the olivocerebellar projection topography.Scientific reports · 2023Article
- How the sense of smell influences cognition throughout life.Neuroforum · 2022Review
- Expression of Maf family proteins in glutamatergic neurons of the mouse olfactory bulb.Developmental neurobiology · 2022Article
- Anatomical and Functional Connectivity at the Dendrodendritic Reciprocal Mitral Cell-Granule Cell Synapse: Impact on Recurrent and Lateral Inhibition.Frontiers in neural circuits · 2022Article
- Neural Circuitry for Stress Information of Environmental and Internal Odor Worlds.Frontiers in behavioral neuroscience · 2022Review
- Processing of Odor Information During the Respiratory Cycle in Mice.Frontiers in neural circuits · 2022Review
- NeuroGT: A brain atlas of neurogenic tagging CreER drivers for birthdate-based classification and manipulation of mouse neurons.Cell reports methods · 2021Article
- Developmental Patterning and Neurogenetic Gradients ofFrontiers in neuroanatomy · 2021Article
- Subpopulations of Projection Neurons in the Olfactory Bulb.Frontiers in neural circuits · 2020Review
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A fundamental strategy in sensory coding is parallel processing, whereby unique, distinct features of sensation are computed and projected to the central target in the form of submodal maps. It remains unclear, however, whether such parallel processing strategy is employed in the main olfactory system, which codes the complex hierarchical odor and behavioral scenes. A potential scheme is that distinct subsets of projection neurons in the olfactory bulb (OB) form parallel projections to the targets. Taking advantage of the observation that the distinct projection neurons develop at different times, we developed a Cre-loxP-based method that allows for birthdate-specific labeling of cell bodies and their axon projections in mice. This birthdate tag analysis revealed that the mitral cells (MCs) born in an early developmental stage and the external tufted cells (TCs) born a few days later form segregated parallel projections. Specifically, the latter subset converges the axons onto only two small specific targets, one of which, located at the anterolateral edge of the olfactory tubercle (OT), excludes widespread MC projections. This target is made up of neurons that express dopamine D1 but not D2 receptor and corresponds to the most anterolateral isolation of the CAP compartments (aiCAP) that were defined previously. This finding of segregated projections suggests that olfactory sensing does indeed involve parallel processing of functionally distinct submodalities. Importantly, the birthdate tag method used here may pave the way for deciphering the functional meaning of these individual projection pathways in the future.
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