Evidence map›Paper›PMID 31672793›Full record

ArticleClinical journal of the American Society of Nephrology : CJASN2019

Varying Association of Extended Hours Dialysis with Quality of Life.

Brendan Smyth, Oliver van den Broek-Best, Daqing Hong, Kirsten Howard, Kris Rogers, Li Zuo, Nicholas A Gray, Janak R de Zoysa, Christopher T Chan, Hongli Lin and 6 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical journal of the American Society of Nephrology : CJASN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00649298 (ACTIVE Dialysis - A Multicentre, Unblinded, Randomised, Controlled Trial to Assess Quality of Life, Clinical Outcomes and Cost Utility for Extended vs Standard Duration of Dialysis in Patients With End Stage Kidney Disease.), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00649298 phase4completednot on this map

ACTIVE Dialysis - A Multicentre, Unblinded, Randomised, Controlled Trial to Assess Quality of Life, Clinical Outcomes and Cost Utility for Extended vs Standard Duration of Dialysis in Patients With End Stage Kidney Disease.

TypeinterventionalSponsorThe George InstituteRan2008 to 2014Enrolled200ConditionsRenal Replacement Therapy, Renal Dialysis, End Stage Kidney Disease, End Stage Renal DiseaseArmshaemodialysis
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Patient-centeredness and the Pareto principle: getting at the matter of what matters to our patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
    Article
  10. Review
  11. How Extended Hemodialysis Treatment Time Can Affect Patient Quality of Life.Clinical journal of the American Society of Nephrology : CJASN · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 4 countries.

Brendan SmythThe George Institute for Global Health, University of New South Wales Sydney, Sydney, Australia.ORCID 0000-0003-1838-3348
Oliver van den Broek-BestDepartment of Medicine, Westmead Hospital, Sydney, Australia.
Daqing HongRenal Department, Sichuan Provincial People's Hospital, Chengdu, China.
Kirsten HowardSydney School of Public Health University of Sydney, Sydney, Australia.
Kris RogersThe George Institute for Global Health, University of New South Wales Sydney, Sydney, Australia.
Li ZuoDepartment of Nephrology, Peking University People's Hospital, Beijing, China.
Nicholas A GrayRenal Department, Sunshine Coast University Hospital, Birtinya, Australia.ORCID 0000-0001-9112-0304
Janak R de ZoysaRenal Services, North Shore Hospital, Auckland, New Zealand.
Christopher T ChanDepartment of Medicine, University Health Network, Toronto, Ontario, Canada.
Hongli LinDepartment of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Ling ZhangDepartment of Nephrology, China-Japan Friendship Hospital, Beijing, China.
Jinsheng XuDepartment of Nephrology, Fourth Hospital Affiliated to Hebei Medical University, Shijiazhuang, China.
Alan CassMenzies School of Health Research, Charles Darwin University, Darwin, Australia; and.
Martin GallagherThe George Institute for Global Health, University of New South Wales Sydney, Sydney, Australia.
Vlado PerkovicThe George Institute for Global Health, University of New South Wales Sydney, Sydney, Australia.
Meg JardineThe George Institute for Global Health, University of New South Wales Sydney, Sydney, Australia.
The University of Sydney · AUConcord Repatriation General Hospital · AUCharles Darwin University · AUChina-Japan Friendship Hospital · CNDalian Medical University · CNHebei Medical University · CNPeking University · CNThe University of Queensland · AUUniversity Health Network · CAUniversity of Auckland · NZUniversity of Electronic Science and Technology of China · CNUniversity of Technology Sydney · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesLittle is known about the effect of changes in dialysis hours on patient-reported outcome measures. We report the effect of doubling dialysis hours on a range of patient-reported outcome measures in a randomized trial, overall and separately for important subgroups. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The A Clinical Trial of IntensiVE Dialysis trial randomized 200 participants to extended or standard weekly hours hemodialysis for 12 months. Patient-reported outcome measures included two health utility scores (EuroQOL-5 Dimensions-3 Level, Short Form-6 Dimension) and their derived quality-adjusted life year estimates, two generic health scores (Short Form-36 Physical Component Summary, Mental Component Summary), and a disease-specific score (Kidney Disease Component Score). Outcomes were assessed as the mean difference from baseline using linear mixed effects models adjusted for time point and baseline score, with interaction terms added for subgroup analyses. Prespecified subgroups were dialysis location (home- versus institution-based), dialysis vintage (≤6 months versus >6 months), region (China versus Australia, New Zealand, Canada), and baseline score (lowest, middle, highest tertile). Multiplicity-adjusted

resultsExtended dialysis hours was associated with improvement in Short Form-6 Dimension (mean difference, 0.027; 95% confidence interval [95% CI], 0.00 to 0.05;

conclusionsThe effect of extended hours hemodialysis on patient-reported outcome measures reached statistical significance in some but not all measures. Within each measure the effect was consistent across predefined subgroups. The clinical importance of these differences is unclear.

Indexed as

Quality of LifeAdultAgedFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresRenal DialysisTime FactorsAustraliaCanadaChinachronic hemodialysisconfidence intervalshome hemodialysishumanskidneykidney diseasesNew Zealandpatient reported outcome measuresquality-adjusted life yearsquality of liferandomized controlled trialsrenal dialysis

Identifiers

PMID31672793
PMCPMC6895496
OpenAlexW2987025679

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.