Evidence map›Paper›PMID 31672790›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Firing Rate Homeostasis Can Occur in the Absence of Neuronal Activity-Regulated Transcription.

Kelsey M Tyssowski, Katherine C Letai, Samuel D Rendall, Chao Tan, Anastasia Nizhnik, Pascal S Kaeser, Jesse M Gray

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. RyR-mediated CaProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  7. Parkinson's disease and translational research.Translational neurodegeneration · 2020
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kelsey M TyssowskiDepartments of Genetics and.ORCID 0000-0002-5324-4872
Katherine C LetaiDepartments of Genetics and.ORCID 0000-0002-5516-3910
Samuel D RendallDepartments of Genetics and.
Chao TanNeurobiology, Harvard Medical School, Boston, Massachusetts 02115.
Anastasia NizhnikDepartments of Genetics and.
Pascal S KaeserNeurobiology, Harvard Medical School, Boston, Massachusetts 02115.ORCID 0000-0002-1558-1958
Jesse M GrayDepartments of Genetics and gray@genetics.med.harvard.edu.
Pediatrics and Genetics · USHarvard University · US

Funding

Dissecting the assembly of vertebrate neurotransmitter release sites-Research Supplements to Promote Diversity in Health-Related ResearchR01MH113349 · NIMH · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2017 to 2026
$6.1M
Genomic mechanisms of firing rate homeostasisR01MH116223 · NIMH · HARVARD MEDICAL SCHOOL · PI DYMECKI, SUSAN M. · 2018 to 2022
$3.0M
NIMH NIH HHS R01 MH113349NIMH NIH HHS R01 MH116223
6 · The paper itself

Abstract

Despite dynamic inputs, neuronal circuits maintain relatively stable firing rates over long periods. This maintenance of firing rate, or firing rate homeostasis, is likely mediated by homeostatic mechanisms such as synaptic scaling and regulation of intrinsic excitability. Because some of these homeostatic mechanisms depend on transcription of activity-regulated genes, including

Indexed as

Transcription, GeneticAction PotentialsAnimalsCells, CulturedCerebral CortexCytoskeletal ProteinsFemaleHomeostasisMaleMiceMice, KnockoutNerve Tissue ProteinsNeuronal PlasticityNeuronsSynapsesactivity regulated cytoskeletal-associated proteinCytoskeletal ProteinsNerve Tissue Proteinsactivity-dependent transcriptionactivity-regulated genesfiring rate homeostasishomeostatic plasticity

Identifiers

PMID31672790
PMCPMC6978944
OpenAlexW2982459672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.