ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Distinct Waking States for Strong Evoked Responses in Primary Visual Cortex and Optimal Visual Detection Performance.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 64 citations in OpenAlex.
- A standardized and reproducible behavioral framework to elicit multiple aspects of visual spatial attention in mice.Cell reports methods · 2026Article
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- Behavioural states control binocular vision through input-specific mechanisms.Nature communications · 2026Article
- Pupil-linked arousal heterogeneously modulates cell-type-specific sensory processing.Science advances · 2026Article
- A standardized and reproducible behavioral protocol to elicit visual spatial attention in mice.bioRxiv : the preprint server for biology · 2025Article
- Walking Modulates Active Auditory Sensing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Adaptive arousal regulation: Pharmacologically shifting the peak of the Yerkes-Dodson curve by catecholaminergic enhancement of arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Environmental context influences visual processing in thalamus.Current biology : CB · 2025Article
- Higher-order thalamic input to cortex selectively conveys state information.Cell reports · 2025Article
- Spiking activity in the visual thalamus is coupled to pupil dynamics across temporal scales.PLoS biology · 2024Article
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- A machine learning approach for real-time cortical state estimation.Journal of neural engineering · 2024Article
- A disinhibitory circuit mechanism explains a general principle of peak performance during mid-level arousal.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for disease.Frontiers in cellular neuroscience · 2024Article
- Transthalamic input to higher-order cortex selectively conveys state information.bioRxiv : the preprint server for biology · 2023Article
- Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobe.Nature communications · 2023Article
- Motor state changes escape behavior of crickets.iScience · 2023Article
- Spontaneous variations in arousal modulate subsequent visual processing and local field potential dynamics in the ferret during quiet wakefulness.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Response outcome gates the effect of spontaneous cortical state fluctuations on perceptual decisions.eLife · 2023Article
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4 authors at 2 institutions in 1 country.
Funding
Abstract
Variability in cortical neuronal responses to sensory stimuli and in perceptual decision making performance is substantial. Moment-to-moment fluctuations in waking state or arousal can account for much of this variability. Yet, this variability is rarely characterized across the full spectrum of waking states, leaving the characteristics of the optimal state for sensory processing unresolved. Using pupillometry in concert with extracellular multiunit and intracellular whole-cell recordings, we found that the magnitude and reliability of visually evoked responses in primary visual cortex (V1) of awake, passively behaving male mice increase as a function of arousal and are largest during sustained locomotion periods. During these high-arousal, sustained locomotion periods, cortical neuronal membrane potential was at its most depolarized and least variable. Contrastingly, behavioral performance of mice on two distinct visual detection tasks was generally best at a range of intermediate arousal levels, but worst during high arousal with locomotion. These results suggest that large, reliable responses to visual stimuli in V1 occur at a distinct arousal level from that associated with optimal visual detection performance. Our results clarify the relation between neuronal responsiveness and the continuum of waking states, and suggest new complexities in the relation between primary sensory cortical activity and behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.