Evidence map›Paper›PMID 31672728›Full record

ArticleThe Journal of experimental biology2019

Controlling and measuring dynamic odorant stimuli in the laboratory.

Srinivas Gorur-Shandilya, Carlotta Martelli, Mahmut Demir, Thierry Emonet

Abstract read
In one paragraph

Article in The Journal of experimental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Simultaneous detection and estimation in olfactory sensing.bioRxiv : the preprint server for biology · 2025
    Article
  3. Mice navigate scent trails using predictive policies.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Experience-dependent plasticity in the olfactory system ofFrontiers in cellular neuroscience · 2023
    Review
  8. Proceedings. Biological sciences · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Adaptive temporal processing of odor stimuli.Cell and tissue research · 2021
    Review
  16. Odor Stimuli: Not Just Chemical Identity.Frontiers in physiology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Srinivas Gorur-ShandilyaInterdepartmental Neuroscience Program, Yale University, New Haven, CT 06511, USA.ORCID 0000-0002-7429-457X
Carlotta MartelliDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.ORCID 0000-0002-5663-6580
Mahmut DemirDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.ORCID 0000-0002-3278-7843
Thierry EmonetInterdepartmental Neuroscience Program, Yale University, New Haven, CT 06511, USA thierry.emonet@yale.edu.ORCID 0000-0002-6746-6564

Funding

The contribution of phenotypic variability to chemotactic performanceR01GM106189 · NIGMS · YALE UNIVERSITY · PI EMONET, THIERRY · 2013 to 2022
$2.6M
NIGMS NIH HHS R01 GM106189
6 · The paper itself

Abstract

Animals experience complex odorant stimuli that vary widely in composition, intensity and temporal properties. However, stimuli used to study olfaction in the laboratory are much simpler. This mismatch arises from the challenges in measuring and controlling them precisely and accurately. Even simple pulses can have diverse kinetics that depend on their molecular identity. Here, we introduce a model that describes how stimulus kinetics depend on the molecular identity of the odorant and the geometry of the delivery system. We describe methods to deliver dynamic odorant stimuli of several types, including broadly distributed stimuli that reproduce some of the statistics of naturalistic plumes, in a reproducible and precise manner. Finally, we introduce a method to calibrate a photo-ionization detector to any odorant it can detect, using no additional components. Our approaches are affordable and flexible and can be used to advance our understanding of how olfactory neurons encode real-world odor signals.

Indexed as

OdorantsOlfactory PerceptionSmellAnimalsKineticsModels, BiologicalAutomationCalibrationMass flow controllerOdor controlOlfactionPhoto-ionization detector

Identifiers

PMID31672728
PMCPMC6918787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.