Evidence map›Paper›PMID 31672705›Full record

ArticleThe Journal of cell biology2019

Structural organization of the C1a-e-c supercomplex within the ciliary central apparatus.

Gang Fu, Lei Zhao, Erin Dymek, Yuqing Hou, Kangkang Song, Nhan Phan, Zhiguo Shang, Elizabeth F Smith, George B Witman, Daniela Nicastro

Abstract read
In one paragraph

Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Mouse radial spoke 3 is a metabolic and regulatory hub in cilia.Nature structural & molecular biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. A look under the hood of the machine that makes cilia beat.Nature structural & molecular biology · 2022
    Article
  13. Cryo-EM structure of an active central apparatus.Nature structural & molecular biology · 2022
    Article
  14. Article
  15. PCD Genes-From Patients to Model Organisms and Back to Humans.International journal of molecular sciences · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gang Fu *Departments of Cell Biology and Biophysics, University of Texas Southwestern Medical Center, Dallas, TX.ORCID 0000-0002-5174-7011
Lei Zhao *Department of Radiology, Division of Cell Biology and Imaging, University of Massachusetts Medical School, Worcester, MA.
Erin DymekDepartment of Biological Sciences, Dartmouth College, Hanover, NH.
Yuqing HouDepartment of Radiology, Division of Cell Biology and Imaging, University of Massachusetts Medical School, Worcester, MA.ORCID 0000-0002-7038-675X
Kangkang SongDepartments of Cell Biology and Biophysics, University of Texas Southwestern Medical Center, Dallas, TX.
Nhan PhanDepartments of Cell Biology and Biophysics, University of Texas Southwestern Medical Center, Dallas, TX.
Zhiguo ShangDepartments of Cell Biology and Biophysics, University of Texas Southwestern Medical Center, Dallas, TX.
Elizabeth F SmithDepartment of Biological Sciences, Dartmouth College, Hanover, NH.
George B WitmanDepartment of Radiology, Division of Cell Biology and Imaging, University of Massachusetts Medical School, Worcester, MA.ORCID 0000-0002-9497-9218
Daniela NicastroDepartments of Cell Biology and Biophysics, University of Texas Southwestern Medical Center, Dallas, TX daniela.nicastro@utsouthwestern.edu.ORCID 0000-0002-0122-7173

Funding

Structure and Function of Complexes that Regulate Ciliary MotilityR01GM083122 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Daniela Nicastro · 2007 to 2026
$6.2M
Flagellar Motility and AssemblyR35GM122574 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WITMAN, GEORGE B · 2017 to 2021
$3.1M
Molecular Mechanisms of Ciliary MotilityR01GM112050 · NIGMS · DARTMOUTH COLLEGE · PI SMITH, ELIZABETH F · 2014 to 2017
$1.2M
NIGMS NIH HHS R01 GM083122NIGMS NIH HHS R01 GM112050NIGMS NIH HHS R35 GM122574
6 · The paper itself

Abstract

Nearly all motile cilia contain a central apparatus (CA) composed of two connected singlet microtubules with attached projections that play crucial roles in regulating ciliary motility. Defects in CA assembly usually result in motility-impaired or paralyzed cilia, which in humans causes disease. Despite their importance, the protein composition and functions of the CA projections are largely unknown. Here, we integrated biochemical and genetic approaches with cryo-electron tomography to compare the CA of wild-type

Indexed as

MutationAxonemeCell MovementChlamydomonasCiliaElectron Microscope TomographyFlagellaGenotypeMicrotubulesMolecular ConformationPhenotypePolymerase Chain Reaction

Identifiers

PMID31672705
PMCPMC6891083

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.