ReviewAntioxidants (Basel, Switzerland)2019
Vitamin C in Plants: From Functions to Biofortification.
Review in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06995586 (The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.), which is not on this map. Cited by 110 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.
Who cites it
110 citing papers in PubMed.
- Bioformulations of Entrophospora lutea enriched with biostimulants for growth promotion and control of Rhizoctonia root rot in lupine.Scientific reports · 2026Article
- Evaluation of the Azotofertil Biostimulant as a Nitrogen-Based Fertilization Strategy forPlants (Basel, Switzerland) · 2026Article
- Potential Antidote Against Lead Toxicity-A Review.International journal of molecular sciences · 2026Review
- Nutritional, Anti-inflammatory, andBiochemistry and biophysics reports · 2026Article
- Primary Metabolites in ThreeLife (Basel, Switzerland) · 2026Article
- Exogenous ascorbic acid enhances drought tolerance in Hypericum perforatum L. by modulating antioxidant defense and osmotic adjustment.Scientific reports · 2026Article
- Effect of Freeze Drying, Hot Air Drying, and Hot Air Drying Preceded by Freezing on Phytochemical Composition, Antioxidant Capacity, and Technological Properties of Mango Peels.Foods (Basel, Switzerland) · 2026Article
- Putrescine mitigates combined drought and nickel stress in Tanacetum balsamita L. through modulation of physiological and biochemical responses.Scientific reports · 2026Article
- Substrate-driven reprogramming of the rhizosphere metabolome underlies enhanced tomato growth and quality in soilless cultivation.Frontiers in plant science · 2026Article
- Natural novel vitamin C derivative, 2-Chinese herbal medicines · 2026Review
- Review
- Effect of Electrical Conductivity of Nutrient Solution and Light Spectra on the Main Phytochemical Content ofPlants (Basel, Switzerland) · 2025Article
- Synergistic Changes in Ascorbic Acid and Soluble Sugar Contents in Apricot Fruits and the Related Regulatory Mechanisms.Food science & nutrition · 2025Article
- Article
- Combined enhancement of ascorbic acid, β-carotene and zeaxanthin in gene-edited lettuce.Plant biotechnology journal · 2025Article
- Tissue- and Condition-Specific Biosynthesis of Ascorbic Acid inInternational journal of molecular sciences · 2025Article
- Advances in Plant-Derived Extracellular Vesicle Extraction Methods and Pharmacological Effects.Biology · 2025Review
- Environmental conditions and nutritional quality of vegetables in protected cultivation.Comprehensive reviews in food science and food safety · 2025Review
- Integrated Analysis of Transcriptomics and Proteomics Provides Insights into the Accumulation Mechanism of Ascorbic Acid inFoods (Basel, Switzerland) · 2025Article
- Vitamin C: From Self-Sufficiency to Dietary Dependence in the Framework of Its Biological Functions and Medical Implications.Life (Basel, Switzerland) · 2025Review
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Vitamin C (l-ascorbic acid) is an excellent free radical scavenger, not only for its capability to donate reducing equivalents but also for the relative stability of the derived monodehydroascorbate radical. However, vitamin C is not only an antioxidant, since it is also a cofactor for numerous enzymes involved in plant and human metabolism. In humans, vitamin C takes part in various physiological processes, such as iron absorption, collagen synthesis, immune stimulation, and epigenetic regulation. Due to the functional loss of the gene coding for l-gulonolactone oxidase, humans cannot synthesize vitamin C; thus, they principally utilize plant-based foods for their needs. For this reason, increasing the vitamin C content of crops could have helpful effects on human health. To achieve this objective, exhaustive knowledge of the metabolism and functions of vitamin C in plants is needed. In this review, the multiple roles of vitamin C in plant physiology as well as the regulation of its content, through biosynthetic or recycling pathways, are analyzed. Finally, attention is paid to the strategies that have been used to increase the content of vitamin C in crops, emphasizing not only the improvement of nutritional value of the crops but also the acquisition of plant stress resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.