Evidence map›Paper›PMID 31671776›Full record

ArticleInternational journal of molecular sciences2019

SAR-mediated Similarity Assessment of the Property Profile for New, Silicon-Based AChE/BChE Inhibitors.

Andrzej Bak, Hana Pizova, Violetta Kozik, Katarina Vorcakova, Jiri Kos, Jakub Treml, Klara Odehnalova, Michal Oravec, Ales Imramovsky, Pavel Bobal and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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  8. Consensus-Based Pharmacophore Mapping for New Set ofInternational journal of molecular sciences · 2020
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  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Andrzej BakInstitute of Chemistry, University of Silesia, Szkolna 9, 40 007 Katowice, Poland. andrzej.bak@us.edu.pl.ORCID 0000-0002-9842-1289
Hana PizovaDepartment of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1, 612 42 Brno, Czech Republic. pizovah@gmail.com.ORCID 0000-0002-7938-5366
Violetta KozikInstitute of Chemistry, University of Silesia, Szkolna 9, 40 007 Katowice, Poland. violetta.kozik@us.edu.pl.
Katarina VorcakovaDepartment of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic. katarina.vorcakova@upce.cz.ORCID 0000-0001-6961-6151
Jiri KosDivision of Biologically Active Complexes and Molecular Magnets, Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacky University, Slechtitelu 27, 783 71 Olomouc, Czech Republic, jiri.kos@upol.cz (J.K.). jiri.kos@upol.cz.
Jakub TremlDepartment of Molecular Biology and Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1, 612 42 Brno, Czech Republic. tremlj@vfu.cz.
Klara OdehnalovaDepartment of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1, 612 42 Brno, Czech Republic. odehnalovak@vfu.cz.
Michal OravecGlobal Change Research Institute CAS, Belidla 986/4a, 60300 Brno, Czech Republic. oravec.m@czechglobe.cz.
Ales ImramovskyInstitute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic. ales.imramovsky@upce.cz.ORCID 0000-0001-9476-9627
Pavel BobalDepartment of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1, 612 42 Brno, Czech Republic. pavelbobal@yahoo.com.ORCID 0000-0002-8429-3810
Adam SmolinskiDepartment of Energy Saving and Air Protection, Central Mining Institute, Plac Gwarkow 1, 40 166 Katowice, Poland. smolin@gig.katowice.pl.ORCID 0000-0002-4901-7546
Zdeněk TrávníčekDivision of Biologically Active Complexes and Molecular Magnets, Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacky University, Slechtitelu 27, 783 71 Olomouc, Czech Republic, jiri.kos@upol.cz (J.K.). zdenek.travnicek@upol.cz.ORCID 0000-0002-5890-7874
Josef JampilekDivision of Biologically Active Complexes and Molecular Magnets, Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacky University, Slechtitelu 27, 783 71 Olomouc, Czech Republic, jiri.kos@upol.cz (J.K.). josef.jampilek@gmail.com.ORCID 0000-0003-2003-9052
University of Veterinary Sciences Brno · CZRegional Centre of Advanced Technologies and Materials · CZUniversity of Pardubice · CZUniversity of Silesia in Katowice · PLCentral Mining Institute · PLCzech Academy of Sciences, Global Change Research Institute · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A set of 25 novel, silicon-based carbamate derivatives as potential acetyl- and butyrylcholinesterase (AChE/BChE) inhibitors was synthesized and characterized by their in vitro inhibition profiles and the selectivity indexes (SIs). The prepared compounds were also tested for their inhibition potential on photosynthetic electron transport (PET) in spinach (

Indexed as

Binding SitesButyrylcholinesteraseCarbamatesCell SurvivalChloroplastsCholinesterase InhibitorsElectron TransportHumansInhibitory Concentration 50LigandsMolecular Docking SimulationPhotosystem II Protein ComplexSiliconSpinacia oleraceaStructure-Activity RelationshipTHP-1 CellsButyrylcholinesteraseCarbamatesCholinesterase InhibitorsLigandsPhotosystem II Protein ComplexSiliconCoMSAin vitro cholinesterase inhibitionIVE-PLSmolecular dockingsilicon-based carbamatessimilarity-activity landscape index

Identifiers

PMID31671776
PMCPMC6862691
OpenAlexW2982485043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.