Trial reportNutrients2019
Maternal Human Milk Oligosaccharide Profile Modulates the Impact of an Intervention with Iron and Galacto-Oligosaccharides in Kenyan Infants.
Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Proteomic profiling in personalized nutrition: a systematic review and methodological frameworks of randomized controlled trials.Frontiers in nutrition · 2026Pooled it
- Maternal gut microbiota in the postpartum Period: A Systematic review.European journal of obstetrics, gynecology, and reproductive biology · 2023Pooled it
- The impact of neonatal intensive care unit antibiotics on gut bacterial microbiota of preterm infants: a systematic review.Frontiers in microbiomes · 2023Pooled it
- Human Milk Oligosaccharide Profile Variation Throughout Postpartum in Healthy Women in a Brazilian Cohort.Nutrients · 2020Trial
- Programming the Infant Gut: How Maternal and Early Life Nutrition Shape the Infant Microbiome and Long-term Health-A Narrative Review.Molecular nutrition & food research · 2026Review
- Associations of known and newly identified human milk oligosaccharides with infections in early childhood: the Ulm SPATZ health study.Frontiers in immunology · 2025Article
- Article
- A Scoping Review Evaluating the Current State of Gut Microbiota Research in Africa.Microorganisms · 2023Article
- The intersection of undernutrition, microbiome, and child development in the first years of life.Nature communications · 2023Review
- Lactational and geographical variation in the concentration of six oligosaccharides in Chinese breast milk: a multicenter study over 13 months postpartum.Frontiers in nutrition · 2023Article
- Biology of human milk oligosaccharides: From basic science to clinical evidence.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022Review
- Human milk nutritional composition across lactational stages in Central Africa.Frontiers in nutrition · 2022Article
- Complementary Feeding and Iron Status: "Nutrients · 2021Review
- The Mean of Milk: A Review of Human Milk Oligosaccharide Concentrations throughout Lactation.Nutrients · 2021Review
- Human Milk Oligosaccharides (HMOs) and Infant Microbiota: A Scoping Review.Foods (Basel, Switzerland) · 2021Article
- Associations of human milk oligosaccharides and bioactive proteins with infant growth and development among Malawian mother-infant dyads.The American journal of clinical nutrition · 2021Article
- Studies and Application of Sialylated Milk Components on Regulating Neonatal Gut Microbiota and Health.Frontiers in nutrition · 2021Review
- The Protective and Long-Lasting Effects of Human Milk Oligosaccharides on Cognition in Mammals.Nutrients · 2020Review
- Review
- Iron Supplementation Influence on the Gut Microbiota and Probiotic Intake Effect in Iron Deficiency-A Literature-Based Review.Nutrients · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
There is little data on human milk oligosaccharide (HMO) composition in Sub-Saharan Africa. Iron fortificants adversely affect the infant gut microbiota, while co-provision of prebiotic galacto-oligosaccharides (GOS) mitigates most of the adverse effects. Whether variations in maternal HMO profile can influence the infant response to iron and/or GOS fortificants is unknown. The aim of this study was to determine HMO profiles and the secretor/non-secretor phenotype of lactating Kenyan mothers and investigate their effects on the maternal and infant gut microbiota, and on the infant response to a fortification intervention with 5 mg iron (2.5 mg as sodium iron ethylenediaminetetraacetate and 2.5 mg as ferrous fumarate) and 7.5 g GOS. We studied mother-infant pairs (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.