Evidence map›Paper›PMID 31671722›Full record

ArticleInternational journal of molecular sciences2019

ATRX Contributes to MeCP2-Mediated Pericentric Heterochromatin Organization during Neural Differentiation.

Domenico Marano, Salvatore Fioriniello, Francesca Fiorillo, Richard J Gibbons, Maurizio D'Esposito, Floriana Della Ragione

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Meta-Analysis IdentifiesInternational journal of molecular sciences · 2022
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  11. Mutant ATRX: pathogenesis of ATRX syndrome and cancer.Frontiers in molecular biosciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Domenico MaranoInstitute of Genetics and Biophysics 'A. Buzzati-Traverso', National Research Council (CNR), 80131 Naples, Italy. domenico.marano@igb.cnr.it.ORCID 0000-0003-0224-8870
Salvatore FiorinielloInstitute of Genetics and Biophysics 'A. Buzzati-Traverso', National Research Council (CNR), 80131 Naples, Italy. salvatore.fioriniello@igb.cnr.it.ORCID 0000-0003-1345-4434
Francesca FiorilloInstitute of Genetics and Biophysics 'A. Buzzati-Traverso', National Research Council (CNR), 80131 Naples, Italy. francesca.fiorillo@igb.cnr.it.
Richard J GibbonsMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK. richard.gibbons@imm.ox.ac.uk.
Maurizio D'EspositoInstitute of Genetics and Biophysics 'A. Buzzati-Traverso', National Research Council (CNR), 80131 Naples, Italy. maurizio.desposito@igb.cnr.it.ORCID 0000-0003-4783-7572
Floriana Della RagioneInstitute of Genetics and Biophysics 'A. Buzzati-Traverso', National Research Council (CNR), 80131 Naples, Italy. floriana.dellaragione@igb.cnr.it.ORCID 0000-0003-1643-6418
Institute of Genetics and Biophysics · ITUniversity of Oxford · GB

Funding

Medical Research Council MC_UU_00016/3Medical Research Council MC_UU_12009/3
6 · The paper itself

Abstract

Methyl-CpG binding protein 2 (MeCP2) is a multi-function factor involved in locus-specific transcriptional modulation and the regulation of genome architecture, e.g., pericentric heterochromatin (PCH) organization.

Indexed as

alpha-ThalassemiaAnimalsCell DifferentiationChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneDisease Models, AnimalEmbryonic Stem CellsGene Expression RegulationGene Knockout TechniquesHeterochromatinIn Situ Hybridization, FluorescenceIntellectual DisabilityMethyl-CpG-Binding Protein 2MiceMutationNeuronsAtrx protein, mouseChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneHeterochromatinMecp2 protein, mouseMethyl-CpG-Binding Protein 2X-linked Nuclear ProteinATRXHP1MECP2neuronspericentric heterochromatinRett syndrome

Identifiers

PMID31671722
PMCPMC6862095
OpenAlexW2981932022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.