Evidence map›Paper›PMID 31671684›Full record

ArticleMolecules (Basel, Switzerland)2019

Synthesis and Antiplasmodial Activity of 1,2,3-Triazole-Naphthoquinone Conjugates.

Sandra Oramas-Royo, Priscila López-Rojas, Ángel Amesty, David Gutiérrez, Ninoska Flores, Patricia Martín-Rodríguez, Leandro Fernández-Pérez, Ana Estévez-Braun

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Triazole analogues as potential pharmacological agents: a brief review.Future journal of pharmaceutical sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sandra Oramas-RoyoInstituto Universitario de Bio-Orgánica (CIBICAN), Departamento de Química Orgánica, Universidad de La Laguna, 38206 Tenerife, Spain. soramas@ull.edu.es.
Priscila López-RojasInstituto Universitario de Bio-Orgánica (CIBICAN), Departamento de Química Orgánica, Universidad de La Laguna, 38206 Tenerife, Spain. priscila.quim@gmail.com.
Ángel AmestyInstituto Universitario de Bio-Orgánica (CIBICAN), Departamento de Química Orgánica, Universidad de La Laguna, 38206 Tenerife, Spain. aarnesty@ull.edu.es.
David GutiérrezInstituto de Investigaciones Fármaco Bioquímicas, Facultad de Ciencias Farmacéuticas y Bioquímicas, Universidad Mayor de San Andrés, Av. Saavedra 2024, 2° piso, Miraflores, La Paz 2314, Bolivia. doyneldavid@yahoo.es.
Ninoska FloresInstituto de Investigaciones Fármaco Bioquímicas, Facultad de Ciencias Farmacéuticas y Bioquímicas, Universidad Mayor de San Andrés, Av. Saavedra 2024, 2° piso, Miraflores, La Paz 2314, Bolivia. ninofq@hotmail.com.
Patricia Martín-RodríguezInstituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Departamento de Ciencias Clínicas, BIOPHARM, Universidad de Las Palmas de Gran Canaria, 35001 Las Palmas de Gran Canaria, Spain. patrimar_bio@hotmail.com.
Leandro Fernández-PérezInstituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Departamento de Ciencias Clínicas, BIOPHARM, Universidad de Las Palmas de Gran Canaria, 35001 Las Palmas de Gran Canaria, Spain. leandrofco.fernandez@ulpgc.es.
Ana Estévez-BraunInstituto Universitario de Bio-Orgánica (CIBICAN), Departamento de Química Orgánica, Universidad de La Laguna, 38206 Tenerife, Spain. aestebra@ull.edu.es.

Funding

MOLECULAR BEACONS FOR PROTEIN DETECTIONR33CA094356 · NCI · SAINT LOUIS UNIVERSITY · PI HEYDUK, TOMASZ · 2004 to 2005
$425k
MOLECULAR BEACONS FOR PROTEIN DETECTIONR21CA094356 · NCI · SAINT LOUIS UNIVERSITY · PI HEYDUK, TOMASZ · 2002 to 2003
$293k
Agencia Canaria de Investigación, Innovación y Sociedad de la Información ProID 2017010071Ministerio de Ciencia e Innovación RTI2018-094356-B-C21Ministerio de Economía y Competitividad SAF2015-65113-C2-1-RMinisterio de Economía y Competitividad SAF2015-65113-C2-2-R
6 · The paper itself

Abstract

A series of 34 1,2,3-triazole-naphthoquinone conjugates were synthesized via copper-catalyzed cycloaddition (CuAAC). They were evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of

Indexed as

AntimalarialsCell Line, TumorHumansInhibitory Concentration 50Models, MolecularNaphthoquinonesPlasmodium falciparumTriazolesAntimalarialsNaphthoquinonesTriazoles1,2,3-triazole-naphthoquinonescopper-catalyzed cycloadditiondockingmalariaPlasmodium falciparum

Identifiers

PMID31671684
PMCPMC6864696

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.