ReviewMolecules (Basel, Switzerland)2019
Guanidine-Containing Polyhydroxyl Macrolides: Chemistry, Biology, and Structure-Activity Relationship.
Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Genome-wide identification, in-silico characterization, and expression analysis of polygalacturonases in different fungal species.Molecular genetics and genomics : MGG · 2026Article
- Unveiling the genomes and secondary metabolomes ofFrontiers in microbiology · 2026Article
- A Novel Antimicrobial Mechanism of Azalomycin F Acting on Lipoteichoic Acid Synthase and Cell Envelope.Molecules (Basel, Switzerland) · 2024Article
- Antibacterial activity of isopropoxy benzene guanidine againstFrontiers in pharmacology · 2024Article
- Isopropoxy Benzene Guanidine AmelioratesInternational journal of molecular sciences · 2023Article
- Marine Macrolides to Tackle Antimicrobial Resistance ofMarine drugs · 2022Review
- Polaramycin B, and not physical interaction, is the signal that rewires fungal metabolism in the Streptomyces-Aspergillus interaction.Environmental microbiology · 2022Article
- Antimicrobial Activity of Lactones.Antibiotics (Basel, Switzerland) · 2022Review
- Kimidinomycin, a new antibiotic against Mycobacterium avium complex, produced by Streptomyces sp. KKTA-0263.The Journal of antibiotics · 2022Article
- An integrated method for optimized identification of effective natural inhibitors against SARS-CoV-2 3CLpro.Scientific reports · 2021Article
- Bacterial marginolactones trigger formation of algal gloeocapsoids, protective aggregates on the verge of multicellularity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Pharmacokinetics of Azalomycin F, a Natural Macrolide Produced by Streptomycete Strains, in Rats.Molecules (Basel, Switzerland) · 2021Article
- Synthetic efforts on the road to marine natural products bearing 4-RSC advances · 2021Review
- Actinomycetes from the Red Sea SpongeMicroorganisms · 2020Article
- Azalomycin FInternational journal of molecular sciences · 2020Article
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Authors and funding
4 authors.
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Abstract
Antimicrobial resistance has been seriously threatening human health, and discovering new antimicrobial agents from the natural resource is still an important pathway among various strategies to prevent resistance. Guanidine-containing polyhydroxyl macrolides, containing a polyhydroxyl lactone ring and a guanidyl side chain, can be produced by many actinomycetes and have been proved to possess many bioactivities, especially broad-spectrum antibacterial and antifungal activities. To explore the potential of these compounds to be developed into new antimicrobial agents, a review on their structural diversities, spectroscopic characterizations, bioactivities, acute toxicities, antimicrobial mechanisms, and the structure-activity relationship was first performed based on the summaries and analyses of related publications from 1959 to 2019. A total of 63 guanidine-containing polyhydroxyl macrolides were reported, including 46 prototype compounds isolated from 33 marine and terrestrial actinomycetes and 17 structural derivatives. Combining with their antimicrobial mechanisms, structure-activity relationship analyses indicated that the terminal guanidine group and lactone ring of these compounds are vital for their antibacterial and antifungal activities. Further, based on their bioactivities and toxicity analyses, the discovery of guanidyl side-chain targeting to lipoteichoic acid of
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