Evidence map›Paper›PMID 31671521›Full record

ArticleInternational journal of molecular sciences2019

Inverse Regulation of Lipocalin-2/24p3 Receptor/SLC22A17 and Lipocalin-2 Expression by Tonicity, NFAT5/TonEBP and Arginine Vasopressin in Mouse Cortical Collecting Duct Cells mCCD(cl.1): Implications for Osmotolerance.

Stephanie Probst, Bettina Scharner, Ruairi McErlean, Wing-Kee Lee, Frank Thévenod

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Stephanie ProbstDepartment of Physiology, Pathophysiology & Toxicology and ZBAF (Centre for Biomedical Education and Research), Faculty of Health, School of Medicine, Witten/Herdecke University, Stockumer Str 12 (Thyssenhaus), D-58453 Witten, Germany. Stephanie.Probst@uni-wh.de.
Bettina ScharnerDepartment of Physiology, Pathophysiology & Toxicology and ZBAF (Centre for Biomedical Education and Research), Faculty of Health, School of Medicine, Witten/Herdecke University, Stockumer Str 12 (Thyssenhaus), D-58453 Witten, Germany. Bettina.Scharner@uni-wh.de.
Ruairi McErleanDepartment of Physiology, Pathophysiology & Toxicology and ZBAF (Centre for Biomedical Education and Research), Faculty of Health, School of Medicine, Witten/Herdecke University, Stockumer Str 12 (Thyssenhaus), D-58453 Witten, Germany. ruairi.mcerlean@student.manchester.ac.uk.
Wing-Kee LeeDepartment of Physiology, Pathophysiology & Toxicology and ZBAF (Centre for Biomedical Education and Research), Faculty of Health, School of Medicine, Witten/Herdecke University, Stockumer Str 12 (Thyssenhaus), D-58453 Witten, Germany. Wing-Kee.Lee@uni-wh.de.ORCID 0000-0002-7352-4679
Frank ThévenodDepartment of Physiology, Pathophysiology & Toxicology and ZBAF (Centre for Biomedical Education and Research), Faculty of Health, School of Medicine, Witten/Herdecke University, Stockumer Str 12 (Thyssenhaus), D-58453 Witten, Germany. frank.thevenod@uni-wh.de.ORCID 0000-0001-8663-3498
Witten/Herdecke University · DE

Funding

Bundesministerium für Forschung und Technologie 01DN16039Centre for Biomedical Training and Research (ZBAF) of the University of Witten/Herdecke Internal Grant SupportDeutsche Forschungsgemeinschaft TH345/11-1
6 · The paper itself

Abstract

The rodent collecting duct (CD) expresses a 24p3/NGAL/lipocalin-2 (LCN2) receptor (SLC22A17) apically, possibly to mediate high-affinity reabsorption of filtered proteins by endocytosis, although its functions remain uncertain. Recently, we showed that hyperosmolarity/-tonicity upregulates SLC22A17 in cultured mouse inner-medullary CD cells, whereas activation of toll-like receptor 4 (TLR4), via bacterial lipopolysaccharides (LPS), downregulates SLC22A17. This is similar to the upregulation of

Indexed as

AnimalsArginine VasopressinCell LineGene Expression RegulationKidney CortexKidney Tubules, CollectingLigandsLipocalin-2MiceOrganic Cation Transport ProteinsOsmolar ConcentrationRatsReceptors, Cell SurfaceSignal TransductionToll-Like Receptor 4Transcription FactorsArginine VasopressinLcn2 protein, mouseLigandsLipocalin-2Nfat5 protein, mouseOrganic Cation Transport ProteinsReceptors, Cell SurfaceSlc22a17 protein, mouseTlr4 protein, mouseToll-Like Receptor 4Transcription FactorsCREBhypertonicitykidneylipocalin-2lipocalin-2 receptorlipopolysaccharideosmotic stressTonEBP

Identifiers

PMID31671521
PMCPMC6862280
OpenAlexW2971370066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.