Evidence map›Paper›PMID 31671441›Full record

ArticleThe Journal of infectious diseases2019

Bacterial Meningitis Epidemiology in Five Countries in the Meningitis Belt of Sub-Saharan Africa, 2015-2017.

Heidi M Soeters, Alpha Oumar Diallo, Brice W Bicaba, Goumbi Kadadé, Assétou Y Dembélé, Mahamat A Acyl, Christelle Nikiema, Adodo Yao Sadji, Alain N Poy, Clement Lingani and 13 more

Abstract readHistorical Article
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  17. Bacterial meningitis in Africa.Frontiers in neurology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Heidi M SoetersNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Alpha Oumar DialloNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Brice W BicabaMinistère de la Santé du Burkina Faso.
Goumbi KadadéMinistère de la Santé Publique du Niger, Niamey, Niger.
Assétou Y DembéléMinistère de la Santé et de l'Hygiène Publique, Bamako, Mali.
Mahamat A AcylMinistère de la Santé Publique du Tchad, N'Djamena, Tchad.
Christelle NikiemaMinistère de la Santé et de la Protection Sociale du Togo, Lomé, Togo.
Adodo Yao SadjiMinistère de la Santé et de la Protection Sociale du Togo, Lomé, Togo.
Alain N PoyWorld Health Organization Regional Office for Africa, Brazzaville, Republic of the Congo.
Clement LinganiWorld Health Organization, AFRO Intercountry Support Team for West Africa.
Haoua TallAgence de Médicine Préventive, Ouagadougou, Burkina Faso.
Souleymane SakandéAgence de Médicine Préventive, Ouagadougou, Burkina Faso.
Félix TarbangdoDavycas International, Ouagadougou, Burkina Faso.
Flavien AkéDavycas International, Ouagadougou, Burkina Faso.
Sarah A MbaeyiNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Jennifer MoïsiAgence de Médicine Préventive, Paris, France.
Marietou F PayeNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Yibayiri Osee SanogoNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Jeni T VuongNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Xin WangNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Olivier RonveauxWorld Health Organization, Geneva, Switzerland.
Ryan T NovakNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
MenAfriNet Consortium

Funding

Intramural CDC HHS CC999999World Health Organization 001
6 · The paper itself

Abstract

backgroundThe MenAfriNet Consortium supports strategic implementation of case-based meningitis surveillance in key high-risk countries of the African meningitis belt: Burkina Faso, Chad, Mali, Niger, and Togo. We describe bacterial meningitis epidemiology in these 5 countries in 2015-2017.

methodsCase-based meningitis surveillance collects case-level demographic and clinical information and cerebrospinal fluid (CSF) laboratory results. Neisseria meningitidis, Streptococcus pneumoniae, or Haemophilus influenzae cases were confirmed and N. meningitidis/H. influenzae were serogrouped/serotyped by real-time polymerase chain reaction, culture, or latex agglutination. We calculated annual incidence in participating districts in each country in cases/100 000 population.

resultsFrom 2015-2017, 18 262 suspected meningitis cases were reported; 92% had a CSF specimen available, of which 26% were confirmed as N. meningitidis (n = 2433; 56%), S. pneumoniae (n = 1758; 40%), or H. influenzae (n = 180; 4%). Average annual incidences for N. meningitidis, S. pneumoniae, and H. influenzae, respectively, were 7.5, 2.5, and 0.3. N. meningitidis incidence was 1.5 in Burkina Faso, 2.7 in Chad, 0.4 in Mali, 14.7 in Niger, and 12.5 in Togo. Several outbreaks occurred: NmC in Niger in 2015-2017, NmC in Mali in 2016, and NmW in Togo in 2016-2017. Of N. meningitidis cases, 53% were NmC, 30% NmW, and 13% NmX. Five NmA cases were reported (Burkina Faso, 2015). NmX increased from 0.6% of N. meningitidis cases in 2015 to 27% in 2017.

conclusionsAlthough bacterial meningitis epidemiology varied widely by country, NmC and NmW caused several outbreaks, NmX increased although was not associated with outbreaks, and overall NmA incidence remained low. An effective low-cost multivalent meningococcal conjugate vaccine could help further control meningococcal meningitis in the region.

Indexed as

AdolescentAdultAfrica South of the SaharaChildChild, PreschoolDisease OutbreaksFemaleHistory, 21st CenturyHumansIncidenceInfantMaleMeningitis, BacterialMiddle AgedPopulation SurveillanceSeasonsbacterial meningitisepidemiologyHaemophilus influenzaemeningitis beltmeningococcal meningitispneumococcal meningitissurveillance

Identifiers

PMID31671441
PMCPMC6853282

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.