Evidence map›Paper›PMID 31671336›Full record

ArticleJournal of pharmaceutical and biomedical analysis2020

NMR reveals an undeclared constituent in custom synthetic peptides.

Mary P Choules, Jonathan Bisson, Charlotte Simmler, James B McAlpine, Gabriel Giancaspro, Anton Bzhelyansky, Matthias Niemitz, Guido F Pauli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical and biomedical analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. QuantitativeMolecules (Basel, Switzerland) · 2026
    Review
  2. Review
  3. The Essential Medicinal Chemistry of Cannabidiol (CBD).Journal of medicinal chemistry · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mary P ChoulesDepartment of Pharmaceutical Sciences, University of Illinois College of Pharmacy, 833 S. Wood St., Chicago 60612, IL, USA; Institute for Tuberculosis Research (ITR), University of Illinois College of Pharmacy, 833 S. Wood St., Chicago, 60612 IL, USA.
Jonathan BissonDepartment of Pharmaceutical Sciences, University of Illinois College of Pharmacy, 833 S. Wood St., Chicago 60612, IL, USA; Institute for Tuberculosis Research (ITR), University of Illinois College of Pharmacy, 833 S. Wood St., Chicago, 60612 IL, USA; Center for Natural Product Technologies (CENAPT), University of Illinois College of Pharmacy, 833 S. Wood St., Chicago, 60612, IL, USA.
Charlotte SimmlerDepartment of Pharmaceutical Sciences, University of Illinois College of Pharmacy, 833 S. Wood St., Chicago 60612, IL, USA; Institute for Tuberculosis Research (ITR), University of Illinois College of Pharmacy, 833 S. Wood St., Chicago, 60612 IL, USA; Center for Natural Product Technologies (CENAPT), University of Illinois College of Pharmacy, 833 S. Wood St., Chicago, 60612, IL, USA.
James B McAlpineDepartment of Pharmaceutical Sciences, University of Illinois College of Pharmacy, 833 S. Wood St., Chicago 60612, IL, USA; Institute for Tuberculosis Research (ITR), University of Illinois College of Pharmacy, 833 S. Wood St., Chicago, 60612 IL, USA; Center for Natural Product Technologies (CENAPT), University of Illinois College of Pharmacy, 833 S. Wood St., Chicago, 60612, IL, USA; Program for Collaboration in the Pharmaceutical Sciences (PCRPS), University of Illinois College of Pharmacy, 833 S. Wood St., Chicago, 60612, IL, USA.
Gabriel GiancasproThe United States Pharmacopeial Convention, 12601 Twinbrook Pkwy., Rockville, 20852, MD, USA.
Anton BzhelyanskyThe United States Pharmacopeial Convention, 12601 Twinbrook Pkwy., Rockville, 20852, MD, USA.
Matthias NiemitzNMR Solutions, Puijonkatu 24 B 5, 70110, Kuopio, Finland.
Guido F PauliDepartment of Pharmaceutical Sciences, University of Illinois College of Pharmacy, 833 S. Wood St., Chicago 60612, IL, USA; Institute for Tuberculosis Research (ITR), University of Illinois College of Pharmacy, 833 S. Wood St., Chicago, 60612 IL, USA; Center for Natural Product Technologies (CENAPT), University of Illinois College of Pharmacy, 833 S. Wood St., Chicago, 60612, IL, USA; Program for Collaboration in the Pharmaceutical Sciences (PCRPS), University of Illinois College of Pharmacy, 833 S. Wood St., Chicago, 60612, IL, USA. Electronic address: gfp@uic.edu.

Funding

900MHz NMR for Structural Biology in ChicagoP41GM068944 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GETTINS, PETER G.W. · 2003 to 2007
$6.2M
Research Training in Natural Product Complementary and Integrative HealthT32AT007533 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Joanna E Burdette, JIMMY ORJALA · 2013 to 2026
$4.3M
Center for Natural Product Technologies at UIC (CeNAPT)U41AT008706 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PAULI, GUIDO F · 2015 to 2019
$1.5M
NCCIH NIH HHS T32 AT007533NCCIH NIH HHS U41 AT008706NIGMS NIH HHS P41 GM068944
6 · The paper itself

Abstract

Whereas generic, LC-based pharmaceutical control quality procedures depend largely on the detection mode and can be particularly 'blind' to certain impurities, NMR is a more versatile and, thus, often more judicious detector. While adulteration presents ever-evolving challenges for the analysis of active pharmaceutical ingredients (APIs) and finished products sold in the worldwide (online) marketplace, research chemicals are usually trusted rather than being considered flawed or even adulterated. This report shows how NMR analysis uncovered the unanticipated presence of substantial amounts of mannitol (20 and 43% w/w) as undeclared constituent in two custom synthetic peptides, DR and DRVYI, that were sourced commercially. Quantitative

Indexed as

Drug ContaminationMagnetic Resonance ImagingPeptidesPharmaceutical PreparationsQuality ControlPeptidesPharmaceutical Preparations(1)H NMRCustom peptide synthesisImpurityPeptidesPurityResidual complexity

Identifiers

PMID31671336
PMCPMC6913887

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.