ArticlePloS one2019
Altered microbiota, fecal lactate, and fecal bile acids in dogs with gastrointestinal disease.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- ACVIM-endorsed statement: consensus statement and systematic review on guidelines for the diagnosis and treatment of chronic inflammatory enteropathy in dogs.Journal of veterinary internal medicine · 2026Pooled it
- Metabolome analyses of the rumen, feces and blood reveal separate and simultaneous impacts of increased dietary concentrate and hindgut starch flow in Holstein cows.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Serum Bile Acid Concentrations in Dogs with Exocrine Pancreatic Insufficiency.Animals : an open access journal from MDPI · 2026Article
- Temporal Dynamics of Clinical Response Following Fecal Microbiota Transplantation in Dogs with Chronic Enteropathy.Animals : an open access journal from MDPI · 2026Article
- Gastrointestinal microbiota and fecal fatty acids of cats with exocrine pancreatic insufficiency.Journal of feline medicine and surgery · 2026Article
- Temporal variability is an inherent feature of the healthy canine microbiome assessed by full-length 16S rRNA gene sequencing.Animal microbiome · 2026Article
- The Collaborative Collapse: Bile Acid Dysmetabolism as a Central Pathogenic Driver in Canine and Feline Multi-Systemic Disorders-From Mechanisms to Precision Therapeutics.Veterinary sciences · 2026Review
- Beneficial effects of a prebiotic-postbiotic supplement on digestive health and fecal microbiota in dogs and cats.Frontiers in veterinary science · 2026Article
- Duodenal mucosal RNA-Seq identifies coordinated bile acid-axis transcriptional alterations in food-responsive enteropathy in dogs.Frontiers in veterinary science · 2026Article
- Preliminary Analysis of Intestinal Microbiota in Golden Retrievers Prone to Dilated Cardiomyopathy Due to Taurine Deficiency.Veterinary sciences · 2025Article
- The domestic cat microbiome: mapping knowledge gaps through scientometric analysis in feline microbial research.Veterinary research communications · 2025Review
- Supplementation of a new combination of prebiotic and postbiotic shapes fecal microbiota of old dogs while influencing immune parameters.Scientific reports · 2025Article
- The fecal metabolome and microbiome are altered in dogs with idiopathic epilepsy compared to healthy dogs.Scientific reports · 2025Article
- Markers of Gut Health in Small Animals: Focus on Fatty Acids and Amino Acids as Indicators of Intestinal Functionality and Microbiome Activity.Animals : an open access journal from MDPI · 2025Review
- Gut Metabolome in Companion Animal Nutrition-Linking Diets to Health.Animals : an open access journal from MDPI · 2025Review
- Age-Related Changes in Gut Health and Behavioral Biomarkers in a Beagle Dog Population.Animals : an open access journal from MDPI · 2025Article
- Impact of an abrupt change from dry to canned diet on digestive function and gut microbiota in dogs.Journal of animal science · 2025Article
- Whole pulse ingredient inclusion in macronutrient-balanced diets increased fecal concentrations of propionic acid but not total bile acids in healthy adult large-breed dogs after 20 weeks.Journal of animal science · 2025Article
- Article
- Effects of Synbiotic Administration on Gut Microbiome and Fecal Bile Acids in Dogs with Chronic Hepatobiliary Disease: A Randomized Case-Control Study.Veterinary sciences · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestinal microbiota plays an important role in health and disease and produces, through fermentative reactions, several metabolic products, such as lactate, that can affect the host. The microbiota also interacts with and metabolizes compounds produced by the host, such as primary bile acids. Lactate and bile acids (BA) are of particular interest in gastrointestinal diseases because they have been associated with metabolic acidosis and bile acid diarrhea, respectively. The objectives of this study were to validate an enzymatic assay to quantify D-, L-, and total lactate in canine feces, and to characterize fecal lactate and BA concentrations as well as bacterial abundances in healthy dogs and dogs with gastrointestinal diseases. Fecal samples were collected from 34 healthy dogs, 15 dogs with chronic enteropathy (CE), and 36 dogs with exocrine pancreatic insufficiency (EPI). Lactate was quantified with an enzymatic assay, BA with gas chromatography-mass spectrometry, and 11 bacterial groups with qPCR. A fecal lactate reference interval was established from 34 healthy dogs and was 0.7-1.4 mM, 0.3-6.0 mM, and 1.0-7.0 mM for D-, L-, and total lactate, respectively. The assay to measure D-, L-, and total lactate in canine fecal samples was linear, accurate, precise, and reproducible. Significant increases in fecal lactate and decreases in secondary BA concentrations were observed in dogs with CE and dogs with EPI. Dogs with EPI had an increased abundance of Escherichia coli, Lactobacillus, and Bifidobacterium; a decreased abundance of Fusobacterium and Clostridium hiranonis; and a higher Dysbiosis Index when compared to healthy dogs. Further studies are necessary to determine the clinical utility of lactate and BA quantification in canine feces. These metabolites suggest functional alterations of intestinal dysbiosis and may become promising targets for further elucidating the role of the microbiota in health and disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.