ArticlePloS one2019
Mathematical modeling of cardiac function to evaluate clinical cases in adults and children.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 49 citations in OpenAlex.
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- Building Digital Twins for Cardiovascular Health: From Principles to Clinical Impact.Journal of the American Heart Association · 2024Review
- Design and Analysis of a Polymeric Left Ventricular Simulator via Computational Modelling.Biomimetics (Basel, Switzerland) · 2024Article
- A mathematical model for simulation of cardiovascular, renal, and hormonal responses to burn injury and resuscitation.Frontiers in physiology · 2024Article
- A Computational Model of Ventricular Dimensions and Hemodynamics in Growing Infants.Journal of biomechanical engineering · 2023Article
- Evaluation of Potential Effects of Increased Outdoor Temperatures Due to Global Warming on Cerebral Blood Flow Rate and Respiratory Function in Chronic Obstructive Disease and Anemia.Global challenges (Hoboken, NJ) · 2023Article
- Computational Modelling of Cerebral Blood Flow Rate at Different Stages of Moyamoya Disease in Adults and Children.Bioengineering (Basel, Switzerland) · 2023Article
- Evaluation of Different Cannulation Strategies for Aortic Arch Surgery Using a Cardiovascular Numerical Simulator.Bioengineering (Basel, Switzerland) · 2023Article
- Patient-Specific Modelling and Parameter Optimisation to Simulate Dilated Cardiomyopathy in Children.Cardiovascular engineering and technology · 2022Article
- CARDIOSIMBioengineering (Basel, Switzerland) · 2022Review
- Multimodal cardiovascular model for hemodynamic analysis: Simulation study on mitral valve disorders.PloS one · 2021Article
- Biomechanics of infarcted left ventricle: a review of modelling.Biomedical engineering letters · 2020Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Time-varying elastance models can simulate only the pressure and volume signals in the heart chambers while the diagnosis of clinical cases and evaluation of different treatment techniques require more information. In this study, an extended model utilizing the geometric dimensions of the heart chambers was developed to describe the cardiac function. The new cardiac model was evaluated by simulating a healthy and dilated cardiomyopathy (DCM) condition for adults and children. The left ventricular ejection fraction, end-diastolic volume, end-diastolic diameter and diastolic sphericity index were 53.60%, 125 mL, 5.08 cm and 1.82 in the healthy adult cardiovascular system model and 23.70%, 173 mL, 6.60 cm and 1.40 in the DCM adult cardiovascular system model. In the healthy child cardiovascular system model, the left ventricular ejection fraction, end-diastolic volume, end-diastolic diameter and diastolic sphericity index were 59.70%, 92 mL, 4.10 cm and 2.26 respectively and 30.70%, 125 mL, 4.94 cm and 1.87 in the DCM child cardiovascular system model. The developed cardiovascular system model simulates the hemodynamic variables and clinical diagnostic indicators within the physiological range for healthy and DCM conditions proving the feasibility of this new model to evaluate clinical cases in adults and children.
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