Evidence map›Paper›PMID 31670841›Full record

Trial reportClinical and experimental immunology2020

Differences in nasal immunoglobulin A responses to influenza vaccine strains after live attenuated influenza vaccine (LAIV) immunization in children.

P J Turner, A F Abdulla, M E Cole, R R Javan, V Gould, M E O'Driscoll, J Southern, M Zambon, E Miller, N J Andrews and 2 more

Open access · hybridAbstract readClinical Trial, Phase IV
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical and experimental immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

P J TurnerNational Heart and Lung Institute, Imperial College London, London, UK.
A F AbdullaDepartment of Infectious Disease, St Mary's Campus, Imperial College London, London, UK.
M E ColeDepartment of Infectious Disease, St Mary's Campus, Imperial College London, London, UK.
R R JavanDepartment of Infectious Disease, St Mary's Campus, Imperial College London, London, UK.
V GouldDepartment of Infectious Disease, St Mary's Campus, Imperial College London, London, UK.
M E O'DriscollInfectious Diseases Epidemiology, St Mary's Campus, Imperial College London, London, UK.
J SouthernPublic Health England (Colindale), London, UK.
M ZambonPublic Health England (Colindale), London, UK.
E MillerPublic Health England (Colindale), London, UK.
N J AndrewsPublic Health England (Colindale), London, UK.
K HöschlerPublic Health England (Colindale), London, UK.
J S TregoningDepartment of Infectious Disease, St Mary's Campus, Imperial College London, London, UK.ORCID 0000-0001-8093-8741
Public Health England · GB

Funding

Medical Research Council MR/K010468/1
6 · The paper itself

Abstract

Different vaccine strains included in the live attenuated influenza vaccine (LAIV) have variable efficacy. The reasons for this are not clear and may include differences in immunogenicity. We report a Phase IV open-label study on the immunogenicity of a single dose of quadrivalent LAIV (Fluenz™ Tetra) in children during the 2015/16 season, to investigate the antibody responses to different strains. Eligible children were enrolled to receive LAIV; nasal samples were collected before and approximately 4 weeks after immunization. There was a significant increase in nasal immunoglobulin (Ig)A to the H3N2, B/Victoria lineage (B/Brisbane) and B/Yamagata lineage (B/Phuket) components, but not to the H1N1 component. The fold change in nasal IgA response was inversely proportional to the baseline nasal IgA titre for H1N1, H3N2 and B/Brisbane. We investigated possible associations that may explain baseline nasal IgA, including age and prior vaccination status, but found different patterns for different antigens, suggesting that the response is multi-factorial. Overall, we observed differences in immune responses to different viral strains included in the vaccine; the reasons for this require further investigation.

Indexed as

ImmunizationAdolescentAntibodies, ViralChildChild, PreschoolFemaleHumansImmunoglobulin AInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza VaccinesMaleNasal CavityVaccines, Live, UnattenuatedAntibodies, ViralImmunoglobulin AInfluenza VaccinesVaccines, Live, Unattenuatedchildreninfluenzanasalpublic healthvaccine

Identifiers

PMID31670841
PMCPMC6954673
OpenAlexW2982494664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.