ArticleCerebral cortex (New York, N.Y. : 1991)2020
Development of Hippocampal-Prefrontal Cortex Interactions through Adolescence.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Air pollution, depressive and anxiety disorders, and brain effects: A systematic review.Neurotoxicology · 2022Pooled it
- Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis.JAMA psychiatry · 2021Pooled it
- Investigation of Esketamine Administration During Surgical Procedures for the Alleviation of Postoperative Anxiety and Depression in Adolescent Patients: A Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
- Towards a neurobiology of early intervention: the importance of critical periods for preventive psychiatry and youth mental health.Molecular psychiatry · 2026Review
- The weight of junk food: Smaller hippocampal, amygdala, and prefrontal volumes in adolescents-The Cogni-Action Project.Applied psychology. Health and well-being · 2026Article
- From adolescence to Alzheimer's: a neurodevelopmental lifespan model of cognitive vulnerability.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Neural correlates of learning speed reveal developmental differences in memory.Developmental cognitive neuroscience · 2026Article
- Increasing representational capacity in the hippocampal-frontoparietal system underlies hierarchical development of temporal memory.Developmental cognitive neuroscience · 2026Review
- Working Memory as a Candidate Mechanism Linking Aging and the Sense of Agency: A Narrative Review.Brain sciences · 2026Review
- Hippocampal representations of temporal structure increase in scale and symmetry across development.bioRxiv : the preprint server for biology · 2026Article
- Network Analysis of Symptom-Level Interrelationships Between Adverse Childhood Experiences and Insomnia Symptoms in Adolescents: A Large-Sample Study.Nature and science of sleep · 2026Article
- Related memories exhibit interference during learning in adults but later retrieval in children.PloS one · 2026Article
- Corticolimbic structure-function coupling is sensitive to childhood adversity and buffers adversity-related symptoms during development.bioRxiv : the preprint server for biology · 2025Article
- Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry.Cell reports · 2025Article
- Prefrontal-hippocampal pathways underlying adolescent resilience.European child & adolescent psychiatry · 2025Article
- Cannabinoid CB1 receptor-sensitive neurodevelopmental processes and trajectories.Molecular psychiatry · 2025Review
- Hormonal contraceptives in adolescence impact the neuroimmune environment of the medial prefrontal cortex and hippocampus in female rats.Brain, behavior, and immunity · 2025Article
- Developmental Differences in a Hippocampal-Cingulate Pathway Involved in Learned Safety Following Interpersonal Trauma Exposure.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- Developmental changes in brain-wide fear memory networks.Neurobiology of learning and memory · 2025Article
- Differentiation of Related Events in Hippocampus Supports Memory Reinstatement in Development.Journal of cognitive neuroscience · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Significant improvements in cognitive control occur from childhood through adolescence, supported by the maturation of prefrontal systems. However, less is known about the neural basis of refinements in cognitive control proceeding from adolescence to adulthood. Accumulating evidence indicates that integration between hippocampus (HPC) and prefrontal cortex (PFC) supports flexible cognition and has a protracted neural maturation. Using a longitudinal design (487 scans), we characterized developmental changes from 8 to 32 years of age in HPC-PFC functional connectivity at rest and its associations with cognitive development. Results indicated significant increases in functional connectivity between HPC and ventromedial PFC (vmPFC), but not dorsolateral PFC. Importantly, HPC-vmPFC connectivity exclusively predicted performance on the Stockings of Cambridge task, which probes problem solving and future planning. These data provide evidence that maturation of high-level cognition into adulthood is supported by increased functional integration across the HPC and vmPFC through adolescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.