ArticleJournal of psychopharmacology (Oxford, England)2020
Lithium-associated hypothyroidism and potential for reversibility after lithium discontinuation: Findings from the LiSIE retrospective cohort study.
Article in Journal of psychopharmacology (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 37 citations in OpenAlex.
- Atorvastatin lowers serum calcium levels in lithium-users: results from a randomized controlled trial.BMC endocrine disorders · 2022Trial
- Amiodarone- and Lithium-Induced Thyroid Dysfunction-Prescriber Specialties Involved in Potential Prescribing Cascades: A Retrospective Study.Health science reports · 2026Article
- Lifelong Pharmacoprophylaxis in Bipolar Disorder: Holy Grail or Hollow Promise?Indian journal of psychological medicine · 2025Article
- Lithium-induced hyperparathyroidism and its potential reversibility in a patient with bipolar affective disorder: case report.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Article
- Insights into the Incidence, Course, and Management of Lithium-Induced Hypothyroidism in Real-World Psychiatric Practice in Italy.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder.Translational psychiatry · 2024Article
- Lithium-Associated Hypothyroidism in a Specialized Lithium Clinic at a Tertiary Care Hospital in Riyadh, Saudi Arabia: A Retrospective Study.Healthcare (Basel, Switzerland) · 2024Article
- Long-Term Lithium Therapy and Thyroid Disorders in Bipolar Disorder: A Historical Cohort Study.Brain sciences · 2023Article
- Incidence of hyperthyroidism in patients with bipolar or schizoaffective disorder with or without lithium: 21-year follow-up from the LiSIE retrospective cohort study.Therapeutic advances in psychopharmacology · 2023Article
- Effects of Toxic Lithium Levels on ECG-Findings from the LiSIE Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- Elevated Thyroxine Concentration and Lithium Intoxication-An Analysis Based on the LiSIE Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- Patterns of Thyroid Hormone Prescription in Patients with Bipolar or Schizoaffective Disorder: Findings from the LiSIE Retrospective Cohort Study.Journal of clinical medicine · 2021Article
- [Clinical practice guidelines for acute and chronic thyroiditis (excluding autoimmune thyroiditis)].Problemy endokrinologii · 2021Article
- The Perfect Storm: Co-occurrence of Agranulocytosis and Thyroid Storm Successfully Managed with Lithium Therapy.Journal of investigative medicine high impact case reportsArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between lithium and thyroid dysfunction has long been known. However, it remains unknown if lithium-associated hypothyroidism is reversible once lithium treatment has been stopped.
aimsTo determine whether lithium-associated hypothyroidism was reversible in patients who subsequently discontinued lithium.
methodsA retrospective cohort study in the Swedish region of Norrbotten into the effects and side- effects of lithium treatment and other drugs for relapse prevention (Lithium - Study into Effects and Side Effects). For this particular study, we reviewed medical records between 1997 and 2015 of patients with lithium-associated hypothyroidism who had discontinued lithium.
resultsOf 1340 patients screened, 90 were included. Of these, 27% had overt hypothyroidism at the start of thyroid replacement therapy. The mean delay from starting lithium to starting thyroid replacement therapy was 2.3 years (SD 4.7). In total, 50% of patients received thyroid replacement therapy within 10 months of starting lithium. Of 85 patients available for follow-up, 41% stopped thyroid replacement therapy after lithium discontinuation. Only six patients reinstated thyroid replacement therapy subsequently. Of these, only one had overt hypothyroidism.
conclusionsLithium-associated hypothyroidism seems reversible in most patients once lithium has been discontinued. In such cases, thyroid replacement therapy discontinuation could be attempted much more often than currently done. Based on the limited evidence of our study, we can expect hypothyroidism to recur early after thyroid replacement therapy discontinuation, if at all.
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