ArticleJournal of psychopharmacology (Oxford, England)2020
Evaluation of the anti-conflict, reinforcing, and sedative effects of YT-III-31, a ligand functionally selective for α3 subunit-containing GABA
Article in Journal of psychopharmacology (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Preclinical evidence for a novel pharmacotherapeutic approach for treating benzodiazepine addiction.Translational psychiatry · 2025Article
- Using a rich-lean transition procedure to evaluate putative antianxiety medications.The Journal of pharmacology and experimental therapeutics · 2025Article
- Evaluation of the sedative-motor effects of novel GABAkine imidazodiazepines using quantitative observation techniques in rhesus monkeys.Journal of psychopharmacology (Oxford, England) · 2024Article
- GABAergic compounds for the treatment of alcohol use disorder.International review of neurobiology · 2024Review
- Pharmaco-EEG analysis of ligands varying in selectivity for α1 subunit-containing GABAPsychopharmacology · 2023Article
- Behavioral effects of triazolam and pregnanolone combinations: reinforcing and sedative-motor effects in female rhesus monkeys.Frontiers in psychiatry · 2023Article
- Alprazolam-induced EEG spectral power changes in rhesus monkeys: a translational model for the evaluation of the behavioral effects of benzodiazepines.Psychopharmacology · 2021Article
- Review
- Tolerance and dependence following chronic alprazolam treatment: quantitative observation studies in female rhesus monkeys.Psychopharmacology · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundIn recent years, pharmacological strategies have implicated α3 subunit-containing GABA
aimsWe investigated the role of α3GABA
methodsFemale and male rhesus monkeys were trained under a conflict procedure (
resultsIn the conflict procedure, increasing doses of YT-III-31 resulted only in dose-dependent attenuation of non-suppressed responding. In the progressive-ratio model of self-administration, YT-III-31 maintained average injections/session above vehicle levels at 0.1 and 0.18 mg/kg/injection. In quantitative observation procedures, YT-III-31 engendered mild sedative effects ("rest/sleep posture"), and deep sedation at the highest dose tested (5.6 mg/kg, i.v.), along with a suppression of tactile/oral exploration and increased observable ataxia. In contrast to other benzodiazepine-like ligands, YT-III-31 uniquely engendered a biphasic dose-response function for locomotion and suppressed self-groom.
conclusionsThe finding that YT-III-31 lacked anti-conflict properties is in accordance with transgenic mouse research indicating no role for α3GABA
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